List of Treatments for Myeloma

Abecma (Idecabtagene vicleucel)

Overview
Abecma is a therapy approved by the U.S. Food and Drug Administration (FDA) to treat adults with relapsed or refractory multiple myeloma after four or more prior therapies, including an immunomodulatory agent,… read more

Adriamycin (Doxorubicin)

The Adriamycin brand name has been discontinued in the U.S. Generic alternatives may be available.

The Adriamycin brand name has been discontinued in the U.S. Generic alternatives may be available.

Overview

Adriamycin is a…

Alkeran (Melphalan)

Overview
Alkeran is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma. Alkeran is often combined with other drugs such as Velcade or Thalomid and a corticost… read more

Allogeneic (donor) stem cell transplant

Overview
Stem cell transplant after high-dose chemotherapy is the most common treatment for people when first diagnosed with multiple myeloma. The purpose of a stem cell transplant in multiple myeloma is to replace… read more

Aredia (Pamidronate)

Overview
Aredia is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat and prevent osteolytic (bone) lesions caused by multiple myeloma. Some doctors may also prescribe Aredia for people… read more

Astramorph (Morphine)

Overview
Astramorph is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain that is not responsive to non-narcotics. Astramorph may also be referred to by its drug name, morphine.… read more

Autologous (self) stem cell transplant

Overview
Stem cell transplant after high-dose chemotherapy is the most common treatment for people when first diagnosed with multiple myeloma. The purpose of a stem cell transplant in multiple myeloma is to replace… read more

Avinza (Morphine)

Overview
Avinza is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat severe pain in cases where long-term, continual pain relief is needed and other treatments are not effective.… read more

Belbuca (Buprenorphine)

Overview
Belbuca is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain in cases where pain is severe enough to require daily, long-term, continual pain relief, and other treatments… read more

BiCNU (Carmustine)

Overview
BiCNU is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma and other cancers. BiCNU is often combined with other drugs such as corticosteroids.… read more

Blenrep (Belantamab mafodotin-blmf)

The Blenrep brand name has been discontinued in the U.S. Other brand name or generic alternatives may be available.

Overview

Blenrep is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat…

Blood transfusion

Overview
In people with myeloma, cancer cells can crowd the bone marrow, preventing the generation of new blood cells. Myeloma treatments including
chemotherapy and radiation therapy can also destroy bone marrow,… read more

Carvykti (Ciltacabtagene autoleucel)

Overview
Carvykti is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat relapsed or refractory multiple myeloma in adults who have already tried at least four lines of therapy.… read more

Chemotherapy

Overview
Chemotherapy is the treatment of cancer with drugs that destroy or slow the growth of cancer cells. Some doctors may refer to all medication prescribed for someone with myeloma as chemotherapy. High-dose… read more

Clinical trials

Overview
Depending on several factors, you may be eligible to participate in clinical trials studying new treatments for myeloma. Clinical trials are the only way that new treatments for myeloma can be tested.… read more

Codeine

Overview
Codeine is approved by the U.S. Food and Drug Administration (FDA) as an analgesic (pain reliever) for mild to moderately severe pain. Codeine is available over the counter or by prescription, depending on the… read more

Complementary and alternative therapies

Overview
Complementary and alternative therapies (CAT) are popular with many people who have myeloma. CAT treatments may be used to help relieve myeloma symptoms, reduce side effects of myeloma treatments, and improve… read more

Corticosteroids

Overview
Corticosteroids are a class of prescription drugs approved by the Food and Drug Administration (FDA) to treat inflammation. Corticosteroids are sometimes used to treat people with myeloma.

The most common… read more

Cymbalta (Duloxetine)

Overview
Cymbalta is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat depression, anxiety, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain. In people… read more

Cytarabine

Overview
Cytarabine is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating several types of leukemia. Cytarabine may be prescribed as part of a chemotherapy regimen to treat… read more

Cytoxan (Cyclophosphamide)

The Cytoxan brand name has been discontinued in the U.S. Generic alternatives may be available.

Overview

Cytoxan is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating cancers…

Darzalex (Daratumumab)

Overview
Darzalex is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma in people who have tried other therapies or who are ineligible for autologous stem… read more

Darzalex Faspro (Daratumumab and Hyaluronidase-Fihj)

Overview
Darzalex Faspro is approved by the U.S. Food and Drug Administration (FDA) for the treatment of multiple myeloma in adults. This treatment is used in combination with other drugs such as bortezomib, lenalidomide…

Dialysis

Overview
In some cases of myeloma, cancer cells secrete abnormal proteins, leading to the development of complications known as amyloidosis and light chain deposition disease. In these conditions, the abnormal proteins… read more

Dilaudid (Hydromorphone)

Overview
Dilaudid is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain in cases where an opioid is appropriate. Dilaudid may be referred to by its drug name, hydromorphone.… read more

Doxepin

Overview
Doxepin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat insomnia. Doxepin is sometimes prescribed to treat neuropathic pain. In people receiving radiation therapy for… read more

Doxil (Doxorubicin liposomal)

Overview

Doxil is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating cancers including multiple myeloma. In cases of myeloma, Doxil is usually combined with Velcade and…

Duragesic (Fentanyl)

Overview
Duragesic is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain in opioid-tolerant patients. Duragesic is also known by its drug name, fentanyl.

Duragesic is an opioid,… read more

Elavil (Amitriptyline)

Overview
Elavil is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat depression. Elavil is sometimes prescribed to manage neuropathic pain, a common side effect of myeloma treatment.… read more

Elrexfio (Elranatamab-Bcmm)

Overview
Elrexfio is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat adults with relapsed or refractory multiple myeloma who’ve received at least four prior lines of therapy,… read more

Empliciti (Elotuzumab)

Overview
Empliciti is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma in people who have tried other therapies. Empliciti is often combined with Pomalyst or Re… read more

Erythropoietin (EPO)

Overview
Erythropoietin is a hormone that stimulates red blood cell production in the bone marrow. Erythropoietin is secreted by the kidneys.

Anemia (low levels of red blood cells) is common in people with myeloma… read more

Evomela (Melphalan)

Overview
Evomela is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma. Evomela is often combined with other drugs such as Velcade or Thalomid and a corticost… read more

Exalgo (Hydromorphone)

Overview
Exalgo is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat severe pain in cases where long-term, continual pain relief is needed and other treatments are not effective.… read more

Exercise

Overview
People with myeloma may avoid exercise due to pain, fatigue, weakness, fear of fractures, or self-consciousness about appearance. Exercise may seem especially out of reach to those undergoing or recovering from… read more

Farydak (Panobinostat)

Overview
Farydak is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma in people who have tried other therapies. Farydak is usually combined with Velcade and a co… read more

Flu and pneumonia vaccinations

Overview
People with myeloma and other types of cancer are at greater risk for severe infections and serious complications from influenza (the flu) and pneumonia. In fact, people with multiple myeloma may be 15 times… read more

Hip replacement

Overview
Hip replacement is surgery to replace one or both hips with artificial joints made from plastic, ceramic, or metal components. Some people with myeloma choose hip replacement to relieve hip pain and increase… read more

Hydrocodone

Overview
Hydrocodone is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain that requires daily, round-the-clock management on a long-term basis, and for which other treatment… read more

Interferon

Overview
Interferon may be referred to more specifically as Interferon alpha-2a or Interferon alpha-2b, or by brand names including Intron A and Roferon-A. In the past, Interferon has been used to modify the immune… read more

Intravenous immunoglobulin (IVIG)

Overview
In myeloma, abnormal versions of white blood cells known as plasma B cells proliferate, crowding out healthy cells and forming tumors. Healthy plasma cells secrete proteins called immunoglobulins – also known… read more

Istodax (Romidepsin)

Overview
Istodax is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat cutaneous T-cell lymphoma in people who have already received at least one systemic therapy. Istodax is sometimes… read more

Kyprolis (Carfilzomib)

Overview
Kyprolis is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma in people who have tried other therapies. Kyprolis is often combined with a corticosteroid… read more

Lyrica (Pregabalin)

Overview
Lyrica is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat fibromyalgia, postherpetic neuralgia, partial onset seizures, and neuropathic pain associated with diabetic… read more

Medical marijuana

Overview
Medical marijuana, also known as medical cannabis, is widely used to treat chronic pain, nausea, vomiting, loss of appetite, and insomnia, all common symptoms of myeloma or side effects of its treatment.… read more

Mozobil (Plerixafor)

Overview
Mozobil is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma and non-Hodgkin lymphoma. Mozobil is also known by its drug name, plerixafor.

Mozobil is a… read more

Neulasta (Pegfilgrastim)

Overview
Neulasta is a prescription drug approved by the Food and Drug Administration (FDA) to lower the risk of developing infections after receiving chemotherapy or some types of radiation. Neulasta is also known by… read more

Neurontin (Gabapentin)

Overview
Neurontin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat postherpetic neuralgia and some types of seizures. In people with myeloma, Neurontin is sometimes prescribed… read more

Ninlaro (Ixazomib)

Overview
Ninlaro is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma in people who have tried at least one other therapy. Ninlaro is often combined with a corti… read more

Norco (Hydrocodone/Acetaminophen)

Overview
Norco is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat moderate to moderately severe pain. Norco is a combination drug containing hydrocodone and acetaminophen.… read more

Norpramin (Desipramine)

Overview
Norpramin is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of depression. Norpramin may be mildly effective at managing neuropathic pain, a common side… read more

Nutrition

Overview
Everyone feels their best when they consistently eat a healthy, balanced diet. For people with myeloma, good nutrition can help you recover from treatment, reduce treatment side effects, support bone health,… read more

Oncovin (Vincristine)

Overview
Oncovin is a prescription medication used to treat several types of cancer. Oncovin is sometimes combined with other drugs such as Adriamycin (doxorubicin) and a corticosteroid in a chemotherapy regimen to… read more

Osenvelt (Denosumab-Bmwo)

Overview
Osenvelt is approved by the U.S. Food and Drug Administration (FDA) to prevent skeletal-related events in people with multiple myeloma and in those with bone metastases from solid tumors. Skeletal-related events…

Oxycodone

Overview
Oxycodone is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain severe enough to require daily, 24-hour, long-term opioid treatment and for which alternative treatment… read more

OxyContin (Oxycodone)

Overview
OxyContin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat pain severe enough to require daily, 24-hour, long-term opioid treatment and for which alternative treatment… read more

Pamelor (Nortriptyline)

Overview
Pamelor is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of depression. Pamelor can also be prescribed to manage neuropathic pain. One study indicates that… read more

Percocet (Oxycodone/Acetaminophen)

Overview
Percocet is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat moderate to moderately severe pain. Sometimes, Percocet is prescribed to treat pain in patients with myeloma.… read more

Plasmapheresis (Plasma exchange)

Overview
In some cases of myeloma, cancer cells secrete abnormal proteins, leading to the development of complications known as hyperviscosity syndrome, amyloidosis, and light chain deposition disease. In hyperviscosity… read more

Platinol (Cisplatin)

Overview
Platinol is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating several types of cancer. Platinol is sometimes combined with other drugs such as VP-16, Cytoxan, and a … read more

Pomalyst (Pomalidomide)

Overview
Pomalyst is a prescription medication approved by the Food and Drug Administration (FDA) to treat multiple myeloma that has progressed after being treated with other therapies. Pomalyst is often combined with a… read more

Pristiq (Desvenlafaxine)

Overview
Pristiq is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat major depression disorder. Pristiq may also be prescribed to manage neuropathic pain, a common side effect of… read more

Radiation therapy

Overview
Radiation therapy (also called radiotherapy) is commonly used to treat solitary plasmacytoma – an early stage of multiple myeloma involving a single lesion in the bone or soft tissues. Plasmacytoma that occurs… read more

Revlimid (Lenalidomide)

Overview
Revlimid is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma. Revlimid is often combined with a corticosteroid like dexamethasone to treat newly… read more

Sarclisa (Isatuximab-Irfc)

Overview
Sarclisa is approved by the U.S. Food and Drug Administration (FDA) for use in adults with multiple myeloma. It is indicated for individuals who have previously received at least two therapies, including…

Spinal surgery

Overview
In myeloma, bone lesions in the spine can cause vertebral compression fractures that lead to severe pain, deformity, and loss of mobility. In cases where symptoms are not improved with nonsurgical treatments… read more

Talvey (Talquetamab-Tgvs)

Overview
Talvey is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat relapsed or refractory multiple myeloma in adults who have already tried at least four lines of therapy. These…

Tecvayli (Teclistamab-cqyv)

Overview
Tecvayli is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat relapsed or refractory multiple myeloma in adults who have already tried at least four lines of therapy. These… read more

Thalomid (Thalidomide)

Overview
Thalomid is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat multiple myeloma. Thalomid is often combined with a corticosteroid like Dexamethasone to treat patients… read more

Treanda (Bendamustine)

Overview
Treanda is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating chronic lymphocytic leukemia and indolent B-cell non-Hodgkin lymphoma. Treanda is sometimes prescribed… read more

Ultram (Tramadol)

Overview
Ultram is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to manage moderate to moderately severe pain in adults. Ultram is also known by its drug name, tramadol.

Ultram is an… read more

Velcade (Bortezomib)

Overview
Velcade is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma. Velcade is often combined with a corticosteroid and other drugs such as Cytoxan, Revli… read more

Vicodin (Hydrocodone/Acetaminophen)

Overview
Vicodin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat moderate to moderately severe pain. Vicodin is a combination drug composed of hydrocodone and acetaminophen.… read more

VP-16 (Etoposide)

Overview
VP-16, also known as VePesid, is a prescription medication approved by the U.S. Food and Drug Administration to treat several types of cancer. VP-16 is sometimes combined with other drugs such as Platinol, Cyto… read more

Xbryk (Denosumab-Dssb)

Overview
Xbryk (denosumab-dssb) is approved by the U.S. Food and Drug Administration (FDA) to help prevent skeletal-related events in people with multiple myeloma or bone metastases from solid tumors. These events can…

Xgeva (Denosumab)

Overview
Xgeva is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to prevent fractures and spinal cord compression in people whose bones have been weakened by multiple myeloma. Xgeva is… read more

Xpovio (selinexor)

Overview
Xpovio is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat relapsed or refractory multiple myeloma in adults who have received at least four prior therapies. Xpovio is also… read more

Zometa (Zoledronic acid)

Overview
Zometa is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat people with multiple myeloma. Some doctors may also prescribe Zometa for people who have monoclonal gammopathy of… read more