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Cymbalta is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat depression, anxiety, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain. In people with myeloma, Cymbalta may be prescribed to treat neuropathy that occurs as a common side effect of myeloma treatment. Cymbalta is also known by its drug name, duloxetine.

Cymbalta is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. Cymbalta is believed to work by changing the balance of neurotransmitters in the brain.

How do I take it?
Cymbalta is taken once or twice daily.

Cymbalta comes in delayed-release capsule form.

Side effects
The FDA-approved label for Cymbalta lists common side effects including nausea, dry mouth, drowsiness, fatigue, constipation, decreased appetite, and increased sweating.

Rare but serious side effects listed for Cymbalta include worsening depression and suicidal thoughts, harm to the liver or kidney, dizziness when standing up, serotonin syndrome, abnormal bleeding, mania, seizures, and blood pressure changes.

For more details about this treatment, visit:


Pain, Pain, Go Away: Antidepressants and Pain Management – National Center for Biotechnology Information

Peripheral neuropathy — Myeloma UK

Managing Treatment-related Peripheral Neuropathy in Patients with Multiple Myeloma — OncologyNurseAdvisor

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