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Darzalex Faspro (daratumumab and hyaluronidase-fihj) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat adults with multiple myeloma. It can be given by itself or with other medicines.
These insights are based on 1,928 comments about Darzalex Faspro from MyMyelomaTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Darzalex Faspro is a type of medicine called a monoclonal antibody. It works by attaching to a protein called CD38, which is found on myeloma cells. This helps the body find and destroy these cancer cells.
By targeting this pathway, the medication may help manage symptoms and slow disease activity.
Doctors prescribe Darzalex Faspro for adults with multiple myeloma. It can be used in people who are newly diagnosed or who have been treated before. It is often given with other medicines, and in some cases it may be used alone.
Darzalex Faspro is given as an injection under the skin, usually in the stomach (abdomen) area. The injection takes about three to five minutes.
Typical Dosing for Multiple Myeloma
The usual dose is 1,800 milligrams of daratumumab and 30,000 units of hyaluronidase given under the skin.
It is often given once a week at first, then every two weeks, and later every four weeks, depending on the treatment plan.
Your doctor may pause treatment if your blood counts get too low.
Darzalex Faspro may be given by itself or with other multiple myeloma medicines. The treatment plan depends on whether you are newly diagnosed or have received treatment before, and whether you can receive a stem cell transplant using your own cells.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 1,928 comments about Darzalex Faspro from MyMyelomaTeam members.Members who use Darzalex Faspro often say it helps to know what the injection schedule is like, keep an eye on side effects and lab results, and stay in close touch with your care team. Many also mention that fatigue and infection risk can be ongoing issues, even when treatment is working well.
Tell your doctor right away about any new symptoms, and stay alert for signs of infection.
“Be sure you let your oncologist or myeloma specialist, whoever is guiding your treatment, know about these symptoms you are having. You will want to be vigilant to avoid infections.”
Ask your doctor what to expect from the dosing schedule.
“It’s weekly for eight weeks, biweekly for eight weeks, then monthly.”
Keep up with blood work and other monitoring.
“I have to have that done every month so I know where my numbers are.”
Connect with others who understand life with multiple myeloma. Join MyMyelomaTeam for free.
In clinical studies of Darzalex Faspro for multiple myeloma in adults, the most common side effects were seen in at least 20 percent of people. Side effects can vary depending on which other medicines are used with Darzalex Faspro. These include:
Darzalex Faspro can cause serious side effects that require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Johnson & Johnson, the manufacturer of Darzalex Faspro, offers the J&J withMe Savings Program. Eligible people with commercial insurance may pay as little as $5 per dose.
The J&J withMe Savings Program also provides one-on-one support through a Care Navigator, who can help explore cost support options, explain available resources, and connect you with community support and services, including transportation assistance.
To learn more, visit the Darzalex savings and support page or call 833-565-9631.
Before starting Darzalex Faspro, your doctor will do a blood test called a “type and screen.” This is because the medicine can affect blood matching tests.
Darzalex Faspro may be given by itself or with other medicines. Your treatment depends on whether you are newly diagnosed or have been treated before, and if you can have a stem cell transplant.
Before each dose, you will receive medicines such as a corticosteroid, acetaminophen, and an antihistamine to help prevent reactions. You may also receive medicines after the dose.
Tell your doctor if you have any allergies to daratumumab and hyaluronidase-fihj or any ingredients in Darzalex Faspro.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements.
Before you receive Darzalex Faspro, tell your doctor about all your medical conditions. This includes if you have breathing problems, have had shingles, or have ever had or may have hepatitis B.
This medicine can cause hepatitis B to become active again. Your doctor will check for signs of this infection before, during, and after treatment.
Do not take Darzalex Faspro if you have had a serious allergic reaction to daratumumab and hyaluronidase-fihj or any of its ingredients.
Darzalex Faspro is also FDA approved to treat high-risk smoldering multiple myeloma and a condition called amyloid light-chain amyloidosis when used with other medicines.
If you miss a dose, get it as soon as possible. Your doctor will adjust your schedule to keep the right timing between doses.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Darzalex Faspro, talk with your doctor about the risks and benefits. Darzalex Faspro can harm your baby if you are pregnant. If you can become pregnant, use effective birth control during treatment and for three months after your last dose.
These answers are fact-checked by our editorial staff.
How effective is Darzalex Faspro?
In clinical studies, adding Darzalex Faspro to treatment helped people with multiple myeloma have better results.
For people who are newly diagnosed and can get a stem cell transplant, the treatment lowered the chance of the cancer getting worse or causing death by 60 percent. Also, 57.5 percent of people had very low levels of cancer, compared with 32.5 percent of people without Darzalex Faspro.
For people who are newly diagnosed but cannot get a stem cell transplant, 52.3 percent of people had very low levels of cancer, compared with 34.8 percent of people without Darzalex Faspro.
For people whose multiple myeloma had come back or did not respond to treatment, those taking Darzalex Faspro lived longer without their cancer getting worse, about 12.4 months compared with 6.9 months.
Results can vary depending on the stage of the disease and treatment.
How often is Darzalex Faspro taken for multiple myeloma?
Darzalex Faspro is given as a shot under the skin over about three to five minutes. It is usually given once a week at first, then every two weeks, and later every four weeks, depending on your treatment plan. Your exact schedule depends on whether it is used alone or with other multiple myeloma medicines.
What should I do if I miss a dose of Darzalex Faspro for multiple myeloma?
If you miss a dose, get it as soon as possible. Your doctor may change your schedule to keep the right timing between doses.
On MyMyelomaTeam, people share their experiences with multiple myeloma, get advice, and find support from others who understand.
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