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HEMATOPOIETIC STEM CELL MOBILIZER
Mozobil (plerixafor) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for use in adults with multiple myeloma to move stem cells into the blood for collection.
These insights are based on 29 comments about Mozobil from MyMyelomaTeam members. These are the experiences of a small number of people and are not meant to be medical advice.
Mozobil is a type of stem cell mobilizer that moves stem cells from the bone marrow into the bloodstream. In multiple myeloma, these stem cells are collected from the blood and later given back in an autologous (to the same person) stem cell transplant.
Doctors prescribe Mozobil to adults with multiple myeloma to help move stem cells into the blood for collection. Mozobil is used together with another medication called filgrastim.
Mozobil is given as an injection under the skin by your healthcare provider. As a first step, another drug called filgrastim is typically given once daily for four days. Then Mozobil can be administered about 11 hours before each stem cell collection session for up to four days.
Typical Dosing for Multiple Myeloma
The recommended dose of Mozobil for people who weigh 83 kilograms or less is 20 milligrams as a fixed dose, or 0.24 milligram per kilogram of body weight, once daily. For people who weigh more than 83 kilograms, the recommended dose is 0.24 milligram per kilogram of body weight once daily, with a maximum of 40 milligrams per day. The dose is based on actual body weight, which is a standard way healthcare providers calculate medicine amounts.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
These insights are based on 29 comments about Mozobil from MyMyelomaTeam members. These are the experiences of a small number of people and are not meant to be medical advice.Members who use Mozobil often talk about balancing treatment logistics with side effects and collection results. Many say it helps to be ready for extra injections, watch for stomach-related side effects, and stay in close contact with the transplant team about how the collection is going.
Be ready for Mozobil to be added during stem cell collection.
“Hooked up to the machine for my second day of stem cell harvest. We only got a third of what we wanted yesterday. Last night they called me back in for a Mozobil injection on top of the filgrastim I was already taking.”
Prepare for stomach-related side effects.
“I made it through the three-line port surgery and stem cell collection (15 million), but man, the Mozobil shot about did me in. Stomach cramps and diarrhea. I was sick for two days.”
Expect a busy schedule around injections and collection.
“Since harvesting begins tomorrow, I have to do a fifth shot tonight of Mozobil. I have to be at the hospital at 6:30 a.m. for central line placement.”
In clinical studies of Mozobil used with filgrastim to help collect stem cells for autologous transplant in adults with multiple myeloma, the most common side effects occurred in between 10 percent and 37 percent of people. They include:
Mozobil can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Sanofi, the manufacturer of Mozobil, offers Sanofi Patient Connection. This program includes Sanofi Patient Assistance Connection which provides Mozobil at no cost to people who meet eligibility requirements.
To learn more, visit Sanofi Patient Connection or call 888-847-4877.
If you are able to become pregnant, your doctor will verify your pregnancy status before starting Mozobil.
Tell your doctor if you have any allergies to plerixafor or any ingredients in Mozobil. Do not take Mozobil if you have had a serious allergic reaction to plerixafor.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, and supplements.
If you are pregnant, planning to become pregnant, or breastfeeding while taking Mozobil, talk with your doctor about the risks and benefits. Mozobil can harm a fetus.
Use effective birth control during treatment and for one week after the final dose (this applies to people of all genders). Breastfeeding is not recommended during treatment and for one week after the final dose of Mozobil.
Mozobil is also FDA approved to mobilize stem cells for collection in adults with non-Hodgkin’s lymphoma.
These answers are fact-checked by our editorial staff.
How effective is Mozobil?
Mozobil can help in the collection of stem cells more quickly and in higher amounts. In a study of people with multiple myeloma, 72 percent of those who took Mozobil with filgrastim collected enough stem cells in two or fewer sessions. This was compared to 34 percent of people who took placebo (an inactive treatment) with filgrastim. On average, it took one day to collect enough stem cells in over half of the patients with Mozobil and four days with placebo.
How long does Mozobil take to work?
Mozobil starts to move stem cells into the blood within a few hours after it is given with filgrastim. In studies, stem cell levels stayed higher from about four to 18 hours after the dose. The highest levels were seen about 10 to 14 hours after the dose was given.
Can Mozobil cause diarrhea?
Yes. Diarrhea was one of the most common side effects reported with Mozobil plus filgrastim, occurring in 37 percent of people, compared with 17 percent of those who received placebo plus filgrastim. Mozobil may also cause other stomach-related side effects, including nausea, vomiting, flatulence, and abdominal pain.
What tests or monitoring are needed with Mozobil?
Doctors need to check certain things when using Mozobil. Blood tests should be reviewed to watch white blood cell counts, because they can go up. Platelet counts should also be checked, because they can go down. Monitoring is important during the injection, and for at least 30 minutes after, to look for any signs or symptoms of allergic reactions.
On MyMyelomaTeam, people share their experiences with multiple myeloma, get advice, and find support from others who understand.
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