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My Dara and Dexa have come to the end of helping me. I was supposed to start in July but I have to postpone it until August. I’m seeking any advice from everyone if they have had side effects or anything I should know about these. Thank you!🫶🏼

June 17
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A MyMyelomaTeam Member

My hematologist-oncologist required a heart scan prior to starting Kyprolis to have a base line to measure against in the event the drug created any issues.

June 18
A MyMyelomaTeam Member

Laurie,
If you start Krypolis, make sure to get a Cardiologist on your team. Many MM team members posted of heart issues after taking it.
Paula🌹

June 18
A MyMyelomaTeam Member

Laurie,

Carfilzomib (Kyprolis) caused me to have extreme shortness of breathe and reduced the ejection function in the left heart ventricle. My doctor took me off of it as soon as he confirmed what was happening, and my heart has recovered.

I have no experience with Pomalidomide. When Revlimid stopped working for me, Pomalidomide was discussed as a possible treatment; however, the consensus was it was too similar to Revlimid and unlikely to be effective for me.

My current treatment is Darzalez FasPro. However, I am on a treatment break to allow my immune system to recover,

June 18
MyMyelomaTeam

Starting a new treatment combo can feel both hopeful and nerve-wracking — totally understandable! Moving to pomalidomide and carfilzomib is a well-recognized option when prior treatments stop working, so you're in good hands medically. Here's what to be aware of: Pomalidomide side effects to watch for:

- Fatigue or Show Full Answer

Starting a new treatment combo can feel both hopeful and nerve-wracking — totally understandable! Moving to pomalidomide and carfilzomib is a well-recognized option when prior treatments stop working, so you're in good hands medically. Here's what to be aware of: Pomalidomide side effects to watch for:

- Fatigue or drowsiness
- Low blood cell counts (which can raise infection risk)
- Constipation
- Neuropathy (tingling or numbness in hands/feet)
- Blood clots — your doctor may recommend aspirin or a blood thinner to help reduce this risk Carfilzomib side effects to watch for:

- Fatigue
- Nausea, diarrhea, or stomach upset
- Low platelet counts
- Fever or headache
- Peripheral neuropathy (nerve-related numbness or weakness) A few important tips going in:

- Be open with your care team about any side effects, even ones that seem minor — they can often help manage them
- Track how you feel day to day so you can report changes accurately
- Don't skip doses — staying consistent with your treatment schedule really matters for the best outcomes
- Blood clot awareness is especially important with pomalidomide, so know the signs (leg swelling, chest pain, shortness of breath)

Wishing you all the strength heading into August! 🫶🏼 Other MyMyelomaTeam members have been through similar transitions and found that knowing what to expect made a big difference.

June 17

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Vancouver, BC

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