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I am going to try and put this problem In a question, what next after Lenalidomide ?

A MyMyelomaTeam Member asked a question 💭
Cathedral City, CA

I have been on Lenalidomide 5MG for 1 year. Went to Oncologist and she said we need to re group. I have been on Darzalex Pro for several years, Zometa for several years and last week she took me off of Lenalidomide and Zometa. I see her next week and she is ordering a PET SCAN, my Beta 2 Microglobulin is now 3.77 and my M Spike is now .5
My counts keep going up instead of down and of course you know I am going to be 84 and she says I am too old for Chemo. I have taken Cyolophophamide for… read more

September 1
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A MyMyelomaTeam Member

Hi Jeafra, Revlimid/Lenalidomide stopped working for me early on. I've been on Pomalyst/Pomalidamide for 9 years. So that might be an option. Also Iberdomide just got approved. As Paula was saying bispecifics could be an option. Is CAR-T an option for you? What about a clinical trial? They might tweak your current treatments to get more mileage out if it. I know it's stressful. We are here with you ❤️

September 4
A MyMyelomaTeam Member

Bi-specific immunotherapy like Talquetamab with Daratumamab might help. City of Hope has a trial for it.
Paula🌹

September 2
MyMyelomaTeam

What options exist when Lenalidomide stops working for myeloma? This is such an important question, and it's completely understandable to feel anxious about what comes next — especially when new side effects are a concern.

Since your myeloma is no longer responding well to Lenalidomide, your oncologist will likely consider Show Full Answer

What options exist when Lenalidomide stops working for myeloma? This is such an important question, and it's completely understandable to feel anxious about what comes next — especially when new side effects are a concern.

Since your myeloma is no longer responding well to Lenalidomide, your oncologist will likely consider switching to different drug combinations. Here are some options doctors commonly explore:

- DPd (daratumumab + pomalidomide + dexamethasone) — works well for people previously treated with Lenalidomide
- IsaPd (isatuximab + pomalidomide + dexamethasone) — particularly helpful for those with kidney concerns or higher-risk myeloma
- DVd (daratumumab + bortezomib + dexamethasone) — proven to extend survival and delay relapse
- VPd (bortezomib + pomalidomide + dexamethasone) — an alternative when other options aren't suitable Pomalidomide (Pomalyst) is worth asking your oncologist about specifically. It's in the same drug family as Lenalidomide but is designed for people whose myeloma has stopped responding to it. It generally causes fewer side effects than older treatments.

Regarding your back pain, radiation is a legitimate and commonly used option for myeloma-related bone pain, especially when it's localized. It's worth discussing this directly with your oncologist next week.

Six years with myeloma at 84 is genuinely remarkable — you've clearly navigated this with real resilience. The PET scan results will give your oncologist much better information to tailor the next steps specifically for you.

September 1
A MyMyelomaTeam Member

Jeafra, I hope all goes well with the PET Scan. Keep positive thoughts!

September 4
A MyMyelomaTeam Member

Thanks Jeff8. When I had a T2 Fracture I took pain pills until the Radation helped. I just don't like pain pills. I use lidocaine patches on Back. I go on Wednesday to hear my blood test results but like I said I have already seem them. She said I was going to get a PET SCAN haven't had one in 2 years.

September 4

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