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A MyMyelomaTeam Member asked a question 💭
Great Britain
August 4
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A MyMyelomaTeam Member

I was on carfilzomib in combination with lenalidomide and dexamethasone as a line of treatment. The carfilzomib is given as an IV infusion. The infusion only takes about 30 minutes. I was typically tired immediately after the infusion. Most of the time, I took a nap in the afternoon because of that. Fortunately, I did not have any other side effects from carfilzomib. That line of treatment was effective for me.

August 4
A MyMyelomaTeam Member

I have been on the same medication as you since May last year.
My.Myeloma was diagnosed in March 2022 and was given Daratumamab, & Velcade with Thylidamide and Dexamethasone. I went into remission after 5 months. Treatment was reduced then stopped. I.remained in remission until May last year. I.have no side effects from the Carfilzomib which I now have 2 days of IV every two weeks. My.problem is the Dexamethasone. I.just cannot sleep after taking 10mg once a week (this was reduced from twice a week). Since my first Chemotherapy my.sleep pattern is terrible so naps in the afternoon help.
If I am still in remission come October the infusions stop but the Lenalidomide & Dexamethasone continue 🙄 as maintenence.

Dave

August 6
MyMyelomaTeam

Carfilzomib (also known by the brand name Kyprolis) is a commonly used myeloma treatment, so there are definitely others in the community who have been on it or are currently taking it!

It belongs to a class of drugs called proteasome inhibitors, which work by stopping myeloma cells from disposing of excess proteins Show Full Answer

Carfilzomib (also known by the brand name Kyprolis) is a commonly used myeloma treatment, so there are definitely others in the community who have been on it or are currently taking it!

It belongs to a class of drugs called proteasome inhibitors, which work by stopping myeloma cells from disposing of excess proteins, essentially causing those cells to die. It can be used alone or in combinations, such as with:

- Dexamethasone
- Dexamethasone and lenalidomide
- Dexamethasone and daratumumab
- Dexamethasone and isatuximab (Sarclisa)

Some common side effects to be aware of include:

- Fatigue
- Low platelet counts
- Anemia
- Nausea, stomach pain, or diarrhea
- Headache
- Fever
- Peripheral neuropathy (numbness or weakness in hands/feet)

One important caution — carfilzomib can affect the heart, potentially leading to irregular heartbeat or heart failure. It's worth keeping up with all recommended blood tests and screenings while on it, and flagging any new symptoms to your care team right away.

August 4

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