Hello, my husband has light chain IgG multiple myeloma, which is classified as very high risk. He also has renal failure. The initial symptom linked to his myeloma was the renal failure itself. Upon his initial diagnosis, his light chain levels exceeded 30,000, his creatinine was 28 (not a misprint), and his blood urea nitrogen (BUN) was 150. He was extremely unwell. They inserted a catheter in his neck, transferred him to the ICU, and performed dialysis throughout the night. Two nurses remained by his bedside throughout the entire night, which felt like the longest night of my life. It wasn't until three weeks later that he was officially diagnosed with multiple myeloma. He never regained any kidney function. He had a asct one year after his diagnosis. He achieved a very good partial remission. They recently discontinued his Revlimid due to neuropathy and Xgeva because he developed osteonecrosis of the jaw. Currently, he is receiving Darzalex Faspro monthly and IVIG, as needed, on a monthly basis. Unfortunately, he has not regained any renal function.

We perform daily home hemodialysis, which he greatly prefers over going to a center three times a week. The dialysis has been more challenging than dealing with the myeloma itself. Home hemodialysis has significantly reduced his fatigue and helped stabilize his blood pressure. When he was receiving treatment at a center, they needed to remove more fluid during each session compared to what we do at home. This would quickly drop his blood pressure, and he described feeling as though he might die. This occurred so frequently that he reacted like a child, almost stamping his feet in frustration each time he had to go for dialysis. While home hemodialysis presents its challenges, it has ultimately been very worthwhile for us.

From what I gather, most renal function is typically restored within the first few months following initial treatment. However, I've also come across information suggesting that some individuals may regain additional renal function after undergoing ASCT. Wishing you good health and Good luck!