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A MyMyelomaTeam Member asked a question 💭
Houston, TX

My husband has Stage 3, IGG Kappa light chain myeloma. He also has kidney failure with more than 50% of his kidney filled with light chain cast nephropathy. Has anyone done plasma exchange instead of dialysis?

July 5, 2025
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MyMyelomaTeam

Light chain myeloma can significantly impact kidney function due to light chains clogging the kidney's filtering system (glomeruli). This buildup can lead to inflammation and kidney tissue damage over time. When kidney function is severely impacted, treatment options need to be considered carefully. About 15% of people with Show Full Answer

Light chain myeloma can significantly impact kidney function due to light chains clogging the kidney's filtering system (glomeruli). This buildup can lead to inflammation and kidney tissue damage over time. When kidney function is severely impacted, treatment options need to be considered carefully. About 15% of people with myeloma require hemodialysis at diagnosis to help their kidneys function. While plasma exchange is a treatment option that can be discussed with your healthcare team, the specific treatment choice should be based on individual factors including the severity of kidney damage, overall health status, and treatment goals. It's important to work closely with your oncology team to determine the most appropriate treatment approach. They can evaluate whether plasma exchange might be suitable in your husband's specific case, considering the extent of his kidney involvement and other clinical factors.

July 5, 2025

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