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(Sarclisa)-VRD Treatment Information

A MyMyelomaTeam Member asked a question 💭
Upper Marlboro, MD

Good evening- my treatment date was changed to Thursday. I am getting the Isatuximab (Sarclisa)-VRD treatment fir the first time (first time diagnosis). I am R-ISS Stage I (Standard); kappa light chains and mild anemia (caused myleoma). Other than the back fractures (Zometa Infusions), blood work normal. Wondering has anyone had this treatment, and what was your experience?

Thank you in advance for sharing.

November 11, 2025
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MyMyelomaTeam

What experiences have MyMyelomaTeam members had with Isatuximab (Sarclisa)-VRD treatment?

Sarclisa is a monoclonal antibody that works by targeting CD38 on myeloma cells and recruiting natural killer cells to destroy them. It's often used in combination treatments like the VRD regimen you're starting.

Common side effects Show Full Answer

What experiences have MyMyelomaTeam members had with Isatuximab (Sarclisa)-VRD treatment?

Sarclisa is a monoclonal antibody that works by targeting CD38 on myeloma cells and recruiting natural killer cells to destroy them. It's often used in combination treatments like the VRD regimen you're starting.

Common side effects to watch for include:

- Diarrhea
- Lower blood cell counts
- Temporary reactions during infusion (fever, chills, dizziness, or trouble breathing)

Your healthcare team will monitor you closely during your first infusion, especially since initial treatments can sometimes cause infusion reactions. Make sure to let them know immediately if you experience any discomfort.

Since you're R-ISS Stage I with otherwise normal blood work, you're starting treatment at a favorable stage. The combination of Sarclisa with VRD has shown effectiveness for newly diagnosed myeloma patients.

Tips from your care team:

- Stay hydrated before and after treatment
- Report any side effects promptly, even if they seem minor
- Keep track of how you're feeling between treatments

Your back fractures are being addressed with Zometa infusions, which help strengthen bones. Continue following up on those alongside your myeloma treatment.

Best wishes with your first treatment on Thursday!

November 11, 2025

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