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A MyMyelomaTeam Member asked a question 💭
Wroughton, UK
August 23, 2025
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MyMyelomaTeam

Fatigue in multiple myeloma is different from regular tiredness and doesn't go away with rest. There are three main causes:

1. Anemia - Myeloma cells interfere with bone marrow function, leading to fewer red blood cells that carry oxygen through your body
2. Cytokines - These immune system proteins can cause persistent Show Full Answer

Fatigue in multiple myeloma is different from regular tiredness and doesn't go away with rest. There are three main causes:

1. Anemia - Myeloma cells interfere with bone marrow function, leading to fewer red blood cells that carry oxygen through your body
2. Cytokines - These immune system proteins can cause persistent inflammation and fatigue similar to fighting off a virus
3. Pain - Physical discomfort from the condition itself can contribute to exhaustion Additional factors that can worsen fatigue include:

• Poor nutrition and difficulty absorbing nutrients
• Dehydration
• Reduced physical activity
• Side effects from treatments
• Sleep problems
• Emotional stress and anxiety from managing the condition

Remember to be patient with yourself - most people with myeloma experience fatigue at some point during their disease or treatment journey. Your healthcare team can help develop strategies to manage these symptoms.

August 23, 2025

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