Fatigue in multiple myeloma is different from regular tiredness and doesn't go away with rest. There are three main causes:
1. Anemia - Myeloma cells interfere with bone marrow function, leading to fewer red blood cells that carry oxygen through your body
2. Cytokines - These immune system proteins can cause persistent Show Full Answer
Fatigue in multiple myeloma is different from regular tiredness and doesn't go away with rest. There are three main causes:
1. Anemia - Myeloma cells interfere with bone marrow function, leading to fewer red blood cells that carry oxygen through your body
2. Cytokines - These immune system proteins can cause persistent inflammation and fatigue similar to fighting off a virus
3. Pain - Physical discomfort from the condition itself can contribute to exhaustion Additional factors that can worsen fatigue include:
• Poor nutrition and difficulty absorbing nutrients
• Dehydration
• Reduced physical activity
• Side effects from treatments
• Sleep problems
• Emotional stress and anxiety from managing the condition
Remember to be patient with yourself - most people with myeloma experience fatigue at some point during their disease or treatment journey. Your healthcare team can help develop strategies to manage these symptoms.
August 23, 2025