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A MyMyelomaTeam Member asked a question 💭
Madrid, Spain

Hi, I have MGUS (low risk according to all parameters, but I have a t(14;16) translocation and high CTCs). I have been diagnosed with breast cancer and have been offered either lumpectomy with radiotherapy OR mastectomy with reconstruction (and no radiotherapy). I am considering many factors, and one of them is whether radiotherapy can trigger or accelerate progression to SMM/MM. I worry because I know a percentage of the high radiation dose received in the breast reaches the ribs (I have been… read more

February 24, 2025
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A MyMyelomaTeam Member

It would be great to get a non-AI answer. Thank you

February 24, 2025
MyMyelomaTeam

For people with low-risk MGUS, the progression risk is about 1% per year. Risk factors that can affect progression include M protein levels above 15 g/L, specific types of M proteins (IgA, IgM, or IgD), and abnormal free light chain ratios in the blood. Regular monitoring is essential for MGUS patients. Your healthcare team Show Full Answer

For people with low-risk MGUS, the progression risk is about 1% per year. Risk factors that can affect progression include M protein levels above 15 g/L, specific types of M proteins (IgA, IgM, or IgD), and abnormal free light chain ratios in the blood. Regular monitoring is essential for MGUS patients. Your healthcare team will typically schedule follow-up appointments every 6-12 months to check for any changes or progression. This monitoring includes blood tests to evaluate protein levels and assess progression risk. Given the complexity of your situation with both MGUS and breast cancer, it would be advisable to discuss your specific concerns about radiation therapy with both your hematologist and oncologist. They can evaluate your individual risk factors and provide guidance based on your complete medical profile.

February 24, 2025

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