Hi, I have MGUS (low risk according to all parameters, but I have a t(14;16) translocation and high CTCs). I have been diagnosed with breast cancer and have been offered either lumpectomy with radiotherapy OR mastectomy with reconstruction (and no radiotherapy). I am considering many factors, and one of them is whether radiotherapy can trigger or accelerate progression to SMM/MM. I worry because I know a percentage of the high radiation dose received in the breast reaches the ribs (I have been… read more
It would be great to get a non-AI answer. Thank you
For people with low-risk MGUS, the progression risk is about 1% per year. Risk factors that can affect progression include M protein levels above 15 g/L, specific types of M proteins (IgA, IgM, or IgD), and abnormal free light chain ratios in the blood. Regular monitoring is essential for MGUS patients. Your healthcare team Show Full Answer