Hopefully your doctor ordered a heart echocadgiogram to establish a baseline prior to starting the Kyprolis. Kyprolis (carfilzomib) is a targeted cancer medication used to treat multiple myeloma. It is well-documented to cause or worsen cardiovascular complications, making heart safety a critical concern during treatment.

@A MyMyelomaTeam Member

Hi Jeanette,

I’m so sorry to hear you will be starting two new medications.
About this time last year you asked about the side effects of Lenolidomide since you were going to start taking it in 5mg dosage.

I explained how I experienced different side effects based on which company manufactured the medicine.

At the time I was on 10 mg and based on my ClonoSEQ test results the number of MM cells was greatly decreasing.

Then my doctor reduced the dosage of Lenolidomide to 5 mg and the MM cells stopped decreasing. The cells dropped to 7 cells per million and just stayed there for a year.
I believe if I have stayed on the 10 mg’s I would have reached MRD negative.

Since my regular labs were normal my doctor took me off Lenolidomide. I'm currently on a drug-free holiday.

After reading your post about the possible side effects of Kyprolis, and how you will be starting Kyprolis and Dexamethasone next week, I can't help from thinking if you had taken 10 mg’s of Revlimid, maybe you would have had a better outcome.

Seeing the possible side effects of Kyprolis, Revlimid’s side effects seem less intense, although I know you had swelling in your feet. I did to.

If you do experience intense side effects from taking Kyprolis and Dexamethasone, maybe 10 mg’s of Revlimid maybe something to consider short term.

If I ever have to go on Revlimid again, I will take the 10 mg since I had such good results with it.

I will keep you in my prayers.

Vicki7 🙏🙏

Mentioned Users

A MyMyelo...

Hi Donna, my P A gave me a new blood Pessure machine that medicare pays for and I take about once a day and the reading goes right into Primary Care Office so that keeps me good on that problem, will keep an eye on it. Thanks for thinking of me.

Dr switched me to TECVAYLI and DARA. working well.

Jeafra, Kyprolis did make my blood pressure go up significantly. I'd never had high blood pressure before. So it wouldn't hurt to take your blood pressure at home. Like Mcastle suggested, a baseline echocardiogram wouldn't be a bad idea either. I remember having one.