Stage 3 myeloma is the most advanced stage, but it's also the least common — so you're in rare company (not exactly the club anyone wants to join, but still). Here's what to know about what stage 3 typically involves:
Symptoms you may experience
- Severe bone pain or damage
- Fatigue
- Frequent infections
- Anemia (low red Show Full Answer
Stage 3 myeloma is the most advanced stage, but it's also the least common — so you're in rare company (not exactly the club anyone wants to join, but still). Here's what to know about what stage 3 typically involves:
Symptoms you may experience:
- Severe bone pain or damage
- Fatigue
- Frequent infections
- Anemia (low red blood cell counts)
- Poor kidney function
What the test results typically show:
- High levels of a protein called beta-2 microglobulin (5.5 mg/L or higher)
- Possible high-risk genetic changes found through a FISH test
- Elevated LDH (lactate dehydrogenase) enzyme levels Treatment options at stage 3 are broad and can include:
- Chemotherapy
- Immunotherapy
- Proteasome inhibitors
- Stem cell transplants
- CAR T-cell therapy
- Radiation therapy
- Steroids and targeted antibody therapies
Treatment is usually personalized to your specific situation, aiming to slow progression and manage symptoms. The five-year survival rate for stage 3 is around 40%, though this continues to improve as new treatments are approved. Stage 3 can progress more quickly than earlier stages, but outcomes vary greatly depending on individual health and how well treatment works.
One MyMyelomaTeam member shared that after a stage 3 diagnosis with failing kidneys, they achieved remission through great medical care — their message was simply: don't give up hope.
Staying on top of your treatment plan and communicating openly with your care team about symptoms and side effects makes a real difference.
October 23
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