MyMyelomaTeam

That's a really valid and frustrating question. While high-risk smoldering myeloma may not have the classic symptoms of active myeloma, the treatment itself — Darzalex — can actually cause back pain and fatigue as side effects, even when the myeloma isn't causing them directly. Darzalex (daratumumab) is known to cause both Show Full Answer

That's a really valid and frustrating question. While high-risk smoldering myeloma may not have the classic symptoms of active myeloma, the treatment itself — Darzalex — can actually cause back pain and fatigue as side effects, even when the myeloma isn't causing them directly. Darzalex (daratumumab) is known to cause both back pain and fatigue in a significant number of people. These are among the most commonly reported side effects, appearing in at least 20% of people using it.

Some other side effects to be aware of include:

- Fatigue — feeling very tired, which can be ongoing even when treatment is working well
- Back pain — can be related to how the drug affects the kidneys and surrounding areas
- Increased infection risk — Darzalex can lower your immune defenses, so watch for any signs of infection
- Muscle or bone pain — general musculoskeletal discomfort is common It's really important to let your care team know about the back pain and fatigue. They may be able to adjust your dosing or suggest ways to manage these side effects. As one MyMyelomaTeam member shared, their care team adjusted doses early on with positive results.

Don't tough it out in silence — speaking up early makes a real difference.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Back Pain and Myeloma: What It Feels Like

Treatments

Darzalex Faspro

Darzalex