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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I’m curious about Car T. Stem cell transplant has mephalin, what meds do they use for car t?

A MyMyelomaTeam Member asked a question 💭
Hartford, CT
May 18
 · 
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A MyMyelomaTeam Member

I'm hoping the new in vivo CAR-T'S don't require lympodepletion medications. I've already had enough of the heavy duty stuff. 😒

May 19
A MyMyelomaTeam Member

I had the SCT in 06/24, would not opt for a second one because of the melphalan. As for CAR-T, I'm not to keen on that treatment option as well.
Don't really know what to do if and when relapse happens.
I've read up on iberdomide, which is given like lenalidomide (21/7) and it seems a much less harsh treatment. Like I said, I'll cross that bridge when I get to it. Long time coming, I hope.

Bristol Myers Squibb - U.S. Food and Drug Administration Accepts Bristol Myers Squibb's New Drug Application for Iberdomide in Patients with Relapsed or Refractory Multiple Myeloma https://share.google/VD5qc13nudGD5P9M2

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May 18
MyMyelomaTeam

Great question! CAR-T cell therapy uses a different preparatory approach than a stem cell transplant. Instead of melphalan, CAR-T uses a process called lymphodepletion — a short course of chemotherapy given before your modified T cells are infused back into your body.

Lymphodepletion typically involves two drugs:

- Show Full Answer

Great question! CAR-T cell therapy uses a different preparatory approach than a stem cell transplant. Instead of melphalan, CAR-T uses a process called lymphodepletion — a short course of chemotherapy given before your modified T cells are infused back into your body.

Lymphodepletion typically involves two drugs:

- Fludarabine
- Cyclophosphamide

These work by clearing out your existing T cells to make room for the new, cancer-fighting CAR-T cells, and to help them thrive once infused. After the CAR-T infusion, doctors closely monitor for side effects. The main ones to be aware of include:

- Cytokine Release Syndrome (CRS) — fever, low blood pressure, and possible organ stress
- Neurological effects (ICANS) — confusion, headaches, or difficulty speaking

Because of these risks, CAR-T is only done at specialized treatment centers, and a hospital stay of two to three weeks is typically required. Always discuss the full process with your care team to understand what to expect.

May 18
A MyMyelomaTeam Member

Donna I agree with you. To many meds.

June 7

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For those of you who had Car T-cell treatment, how long was/is your remission?

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