Neuropathy is very common with myeloma — around 75% of people develop it during treatment. There are two main sources of the problem: the disease itself and the treatments used to fight it.
How myeloma causes neuropathy
- Myeloma can produce abnormal proteins (M proteins) that directly damage nerves
- Tumors can press on Show Full Answer
Neuropathy is very common with myeloma — around 75% of people develop it during treatment. There are two main sources of the problem: the disease itself and the treatments used to fight it.
How myeloma causes neuropathy:
- Myeloma can produce abnormal proteins (M proteins) that directly damage nerves
- Tumors can press on nerves, causing pain, tingling, or numbness
- High calcium levels in the blood can also contribute to nerve-related symptoms How myeloma treatments cause neuropathy:
- Chemotherapy-induced peripheral neuropathy (CIPN) is actually the most common cause
- Certain immunomodulatory drugs used in treatment can damage or worsen nerve health
As one MyMyelomaTeam member shared, a neurologist told them: *"You have multiple myeloma, you're on chemo. Both of those things cause neuropathy."*
The good news is that for some people, neuropathy improves after treatment ends or when doses are adjusted. However, for others it can persist long-term. It's always worth talking to your oncology team — they can help manage symptoms and review whether any treatment adjustments might help.
May 13
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