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A MyMyelomaTeam Member asked a question πŸ’­
Lake Charles, LA

https://www.instagram.com/reel/DWXf-A3jI1d/?igs...

The p53 gene (specifically TP53) is a critical tumor suppressor gene, often called the "guardian of the genome," that prevents cancer by repairing damaged DNA or inducing cell death (apoptosis) in damaged cells. Mutations in p53 are found in over 50% of all human cancers, leading to uncontrollable cell growth and tumor formation.Key Aspects of the p53 Gene:Function: Located in the nucleus, the p53 protein acts as a transcription factor, binding… read more

π—žπ—”π—¬π—Ÿπ—˜π—˜ 𝗠𝗔π—₯π—œπ—˜οΌ©π‘Ήπ’π’π’• π‘ͺ𝒂𝒖𝒔𝒆 π‘·π’“π’‚π’„π’•π’Šπ’•π’Šπ’π’π’†π’“ on Instagram: "Iodine is essential to helping your thyroid produce hormones.
When you don’t have enough iodine, the thyroid works extra hard to make hormones causing the gland to grow larger.
2 BILLION people worldwide.
-thyroid issues are linked to iodine deficiency & iodine deficiency is due to fluoride, aluminum, SLS, parabens, chlorine & sulfates!
These also affect our babies’ development:
baby teeth that don’t fall out, mouth breathing, and crooked teeth.
Your body has something called p53 known as the β€œguardian of your cells.”
Its job is to detect damaged or abnormal cells and either repair them… or signal them to break down and be removed.
Many damaged or diseased cells disrupt or avoid p53, which allows them to survive longer than they should.
Iodine has been studied for its ability to support healthy cellular turnover & apoptosis (natural cell breakdown) including pathways that work alongside of p53.
Meaning iodine doesn’t just support hormones… it supports how your body handles damaged cells at a deeper level.
Earlier signs of iodine deficiency may be:
β€’ Weight gain: because thyroid hormones help control the speed of your metabolism
β€’ Fatigue and weakness: nearly 80% of with low thyroid  report low energy
β€’ Feeling cold is a common symptom of an iodine deficiency
β€’ Poor memory: A study including over 1,000 adults found that those with higher thyroid hormone levels performed better on learning and memory tests
Adequate amounts of iodine are essential for the health of all the glands in the human body.
The thyroid gland is a small, butterfly shaped gland in the front of your neck. It makes thyroid hormones upon receiving a signal from the thyroid-stimulating hormone.
The thyroid gland uses iodine to make thyroid hormones. However, when your body is low in iodine, it can’t make enough of them.
Iodine may also be interrupted if similar elements are absorbed in the body from the halide chemical group.
Over time the cells work harder to try to make more. This causes the cells to grow and multiply, eventually leading to a goiter.
This isn’t just deficiency…
this is interference
Comment IODINE natural iodine protocol use daily πŸ‘"
π—žπ—”π—¬π—Ÿπ—˜π—˜ 𝗠𝗔π—₯π—œπ—˜οΌ©π‘Ήπ’π’π’• π‘ͺ𝒂𝒖𝒔𝒆 π‘·π’“π’‚π’„π’•π’Šπ’•π’Šπ’π’π’†π’“ on Instagram: "Iodine is essential to helping your thyroid produce hormones. When you don’t have enough iodine, the thyroid works extra hard to make hormones causing the gland to grow larger. 2 BILLION people worldwide. -thyroid issues are linked to iodine deficiency & iodine deficiency is due to fluoride, aluminum, SLS, parabens, chlorine & sulfates! These also affect our babies’ development: baby teeth that don’t fall out, mouth breathing, and crooked teeth. Your body has something called p53 known as the β€œguardian of your cells.” Its job is to detect damaged or abnormal cells and either repair them… or signal them to break down and be removed. Many damaged or diseased cells disrupt or avoid p53, which allows them to survive longer than they should. Iodine has been studied for its ability to support healthy cellular turnover & apoptosis (natural cell breakdown) including pathways that work alongside of p53. Meaning iodine doesn’t just support hormones… it supports how your body handles damaged cells at a deeper level. Earlier signs of iodine deficiency may be: β€’ Weight gain: because thyroid hormones help control the speed of your metabolism β€’ Fatigue and weakness: nearly 80% of with low thyroid report low energy β€’ Feeling cold is a common symptom of an iodine deficiency β€’ Poor memory: A study including over 1,000 adults found that those with higher thyroid hormone levels performed better on learning and memory tests Adequate amounts of iodine are essential for the health of all the glands in the human body. The thyroid gland is a small, butterfly shaped gland in the front of your neck. It makes thyroid hormones upon receiving a signal from the thyroid-stimulating hormone. The thyroid gland uses iodine to make thyroid hormones. However, when your body is low in iodine, it can’t make enough of them. Iodine may also be interrupted if similar elements are absorbed in the body from the halide chemical group. Over time the cells work harder to try to make more. This causes the cells to grow and multiply, eventually leading to a goiter. This isn’t just deficiency… this is interference Comment IODINE natural iodine protocol use daily πŸ‘"
May 9
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Answer Summary

Members discussed the TP53/17p deletion in the context of multiple myeloma, with several sharing their personal diagnoses and treatment... Read more

Members discussed the TP53/17p deletion in the context of multiple myeloma, with several sharing their personal diagnoses and treatment experiences, including one member living well beyond their initial 18-month prognosis without a stem cell transplant. A recurring theme was the importance of FISH testing to detect 17p deletions, and members mentioned treatments like Darzalex and Pomalyst helping them stay stable. One member flagged a linked source as spreading false medical information to sell products, and the community also noted that while research into MDM2 inhibitors and other therapies is ongoing, no FDA-approved p53-targeted treatments currently exist.

A MyMyelomaTeam Member

I do.have the 17p (TP53) deletion detected and beta-2-microglobulin of 5.56 a double hit of Stage 3 MM, I was given 18 months at diagnosis. I am here more than 2 years later with no SCT and asymptomatic tolerating treatments well. The experts still have a lot to learn about MM.

May 9 (edited)
A MyMyelomaTeam Member

Beware please! Kaylee Marie in the link above have been found to be giving out scientifically and medically false information. She has been found to expound on appalling health claims in order to sell unproven detox products.
Her background is multi level marketing, supplement sales and self publishing.
She is known for creating medical fear in order to sell products.
As to P53 treatments, there are no FDA approved treatments at the moment, though there is research ongoing

May 23
A MyMyelomaTeam Member

I have 17p/P53 deletion on my fish testing. Only on my myeloma cells. It can make myeloma harder to treat. I have never reached mrd negativity, but I'm stable on Darzalex and Pomalyst at the present time.

May 10
A MyMyelomaTeam Member

4. Dietary Compounds Under Research
While a healthy diet supports overall wellness during cancer treatment, natural compounds cannot replace targeted therapies. However, researchers are studying certain natural compounds that influence the p53 pathway in laboratory settings:
* EGCG (Green Tea Extract): Some laboratory studies suggest certain components in green tea can interfere with microRNAs that naturally suppress p53, slightly improving its baseline function.
* Apigenin: Found in foods like parsley, celery, and chamomile, this compound has been observed in early lab models to help shift sequestered p53 back into the cell nucleus where it belongs.

Apigenin is a natural plant flavonoid found in high amounts in Chamomile, parsley, and celery.

Top Dietary Sources of Apigenin
* Chamomile: Dried chamomile flowers and tea are among the richest sources.
*
* Parsley: Both fresh and dried parsley contain very high levels, far exceeding most other vegetables.
*
* Celery and Celeriac: Fresh stalks, celery seeds, and celery hearts provide steady dietary amounts.
*
* Herbs and Spices: Oregano, thyme, basil, rosemary, and marjoram contain notable concentrations.
*
* Fruits: Oranges, grapefruits, kumquats, and guavas offer smaller amounts.
*
* Vegetables: Artichokes, onions, rutabagas, and vine spinach contribute to daily intake.
*
* Beverages: Plant-based drinks like red wine and beer contain trace levels.

October 2
A MyMyelomaTeam Member

Wow you all know way more then me

May 22

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