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The p53 gene (specifically TP53) is a critical tumor suppressor gene, often called the "guardian of the genome," that prevents cancer by repairing damaged DNA or inducing cell death (apoptosis) in damaged cells. Mutations in p53 are found in over 50% of all human cancers, leading to uncontrollable cell growth and tumor formation.Key Aspects of the p53 Gene:Function: Located in the nucleus, the p53 protein acts as a transcription factor, binding⦠read more
Answer Summary
Members discussed the TP53/17p deletion in the context of multiple myeloma, with several sharing their personal diagnoses and treatment... Read more
I do.have the 17p (TP53) deletion detected and beta-2-microglobulin of 5.56 a double hit of Stage 3 MM, I was given 18 months at diagnosis. I am here more than 2 years later with no SCT and asymptomatic tolerating treatments well. The experts still have a lot to learn about MM.
Beware please! Kaylee Marie in the link above have been found to be giving out scientifically and medically false information. She has been found to expound on appalling health claims in order to sell unproven detox products.
Her background is multi level marketing, supplement sales and self publishing.
She is known for creating medical fear in order to sell products.
As to P53 treatments, there are no FDA approved treatments at the moment, though there is research ongoing
4. Dietary Compounds Under Research
While a healthy diet supports overall wellness during cancer treatment, natural compounds cannot replace targeted therapies. However, researchers are studying certain natural compounds that influence the p53 pathway in laboratory settings:
* EGCG (Green Tea Extract): Some laboratory studies suggest certain components in green tea can interfere with microRNAs that naturally suppress p53, slightly improving its baseline function.
* Apigenin: Found in foods like parsley, celery, and chamomile, this compound has been observed in early lab models to help shift sequestered p53 back into the cell nucleus where it belongs.
Apigenin is a natural plant flavonoid found in high amounts in Chamomile, parsley, and celery.
Top Dietary Sources of Apigenin
* Chamomile: Dried chamomile flowers and tea are among the richest sources.
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* Parsley: Both fresh and dried parsley contain very high levels, far exceeding most other vegetables.
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* Celery and Celeriac: Fresh stalks, celery seeds, and celery hearts provide steady dietary amounts.
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* Herbs and Spices: Oregano, thyme, basil, rosemary, and marjoram contain notable concentrations.
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* Fruits: Oranges, grapefruits, kumquats, and guavas offer smaller amounts.
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* Vegetables: Artichokes, onions, rutabagas, and vine spinach contribute to daily intake.
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* Beverages: Plant-based drinks like red wine and beer contain trace levels.
Wow you all know way more then me