Great question! The approach to treating MGUS and smoldering myeloma (SMM) depends on the stage and risk level. Here's a breakdown:
MGUS
MGUS is typically not treated directly. Instead, the focus is on careful monitoring, including regular blood and urine tests every 6 to 12 months. The goal is to catch any progression Show Full Answer
Great question! The approach to treating MGUS and smoldering myeloma (SMM) depends on the stage and risk level. Here's a breakdown:
MGUS
MGUS is typically not treated directly. Instead, the focus is on careful monitoring, including regular blood and urine tests every 6 to 12 months. The goal is to catch any progression early.
Symptoms caused by MGUS, like nerve pain, may be managed with medication if they become severe.
Smoldering Myeloma (SMM)
SMM also often involves a "watchful waiting" approach, but treatment may be recommended sooner for high-risk cases. Options being used or studied include:
- Bisphosphonates (e.g., Zometa, Xgeva) to protect bone strength
- Revlimid (lenalidomide) combined with low-dose Decadron (dexamethasone), which has shown promise in reducing the chance of progressing to active myeloma
- Daratumumab (Darzalex), currently being studied in clinical trials for MGUS and SMM
Symptoms to watch for that may signal progression include bone pain, nerve pain, fatigue, unexplained weight loss, and night sweats.
Talking openly with your care team about your risk level is the best way to figure out the right path forward for you.
April 28
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