I am if the same mindset. Have read quite a bit about the medication, side effects, length of treatment
December 20, 2025
I think it’s interesting the mymyeloma team AI generated answer is wrong. FDA recently approved treatment for high risk SMM. Fact. What is left to doctor’s interpretation is what is high risk. FDA doesn’t specify. I’ve not asked for treatment yet, for now will follow levels. If I see a spike, yes.
December 20, 2025
Has anyone signed up for or started treatment with daratumumab for smoldering myeloma?
Daratumumab is being studied in clinical trials for people with smoldering myeloma and MGUS, though it's primarily FDA-approved for active multiple myeloma. One trial that launched in 2017 includes adults with MGUS or smoldering myeloma Show Full Answer
Has anyone signed up for or started treatment with daratumumab for smoldering myeloma?
Daratumumab is being studied in clinical trials for people with smoldering myeloma and MGUS, though it's primarily FDA-approved for active multiple myeloma. One trial that launched in 2017 includes adults with MGUS or smoldering myeloma receiving IV infusions of daratumumab. Researchers are monitoring safety, side effects, and whether participants progress to multiple myeloma.
There's also growing evidence that early treatment with medications like lenalidomide and low-dose dexamethasone may help reduce the chances of developing active myeloma for people with higher-risk smoldering myeloma.
If you're interested in treatment options or clinical trials for smoldering myeloma, it's worth discussing with your healthcare team. They can help you understand the risks and benefits based on your specific situation.
Have you talked with your doctor about whether early treatment might be right for you?
December 17, 2025