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I had MM diagnosed in January started quad treatment but it was too aggressive so I had chemotherapy done instead. My levels have been low since the chemo but kept having fractures even with myeloma gone. Doctors want me to start on zometa

April 27
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MyMyelomaTeam

Zometa (zoledronic acid) is a bisphosphonate commonly used in myeloma to help protect bones and reduce fractures — so it makes sense your doctors are recommending it given your fracture history.

It's typically given as an IV infusion, often monthly at first, though frequency can be reduced over time depending on your Show Full Answer

Zometa (zoledronic acid) is a bisphosphonate commonly used in myeloma to help protect bones and reduce fractures — so it makes sense your doctors are recommending it given your fracture history.

It's typically given as an IV infusion, often monthly at first, though frequency can be reduced over time depending on your response and how your kidneys are tolerating it. Dental health is a really important consideration before starting Zometa. It's linked to a condition called osteonecrosis of the jaw (ONJ), where bone tissue in the jaw can be affected. ONJ affects roughly 3–11% of people taking bisphosphonates, and risk increases the longer you're on it.

Before starting, it's strongly recommended to:
- Get a full dental exam
- Address any existing dental issues that might need surgery
- Avoid invasive procedures like extractions or implants once on Zometa
- If invasive dental work is unavoidable, Zometa should be paused for 90 days before and after

Safer dental work like cleanings, fillings, and crowns can generally continue during treatment. Signs of ONJ to watch for include:
- Loose teeth
- Exposed jawbone
- Pus or discharge in the mouth
- Unusual swelling or tenderness

One MyMyelomaTeam member shared that their ONJ was actually caught early during a routine dental exam — which is a great reminder of why regular checkups matter.

Make sure your oncologist and dentist are communicating with each other throughout your treatment. Many dentists don't regularly treat people with myeloma, so keeping them informed is key.

April 27
A MyMyelomaTeam Member

I’ve had many infusions of Zometa. Before I started I had a consultation with my dentist whose advice was to continue with regular preventative cleanings and exams and to rinse with a fluoride solution. His only experience of jaw necrosis was with a patient with existing poor oral hygiene who had had an extraction. Hope this helps.

May 4
A MyMyelomaTeam Member

I have been on Zometa quarterly for a few cycles now. I just got an infusion yesterday. To date a day of flu like symptoms is all I experienced. That after the the 2nd round.

April 30
A MyMyelomaTeam Member

I take Claritin not Claritin D just plain and it helps. 5 days after Zometa.

May 3
A MyMyelomaTeam Member

I had a tooth pulled in January 2026. Had to stop Zometa for about 4 months before tooth got pulled, resume infusion on May 5.

April 29

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