MyMyelomaTeam

What's causing your diarrhea with myeloma?

Diarrhea can stem from several myeloma-related causes. The disease itself can lead to amyloidosis, where proteins build up in organs and cause digestive issues. Treatment is another common culprit - chemotherapy drugs like Revlimid (lenalidomide) frequently cause diarrhea by Show Full Answer

What's causing your diarrhea with myeloma?

Diarrhea can stem from several myeloma-related causes. The disease itself can lead to amyloidosis, where proteins build up in organs and cause digestive issues. Treatment is another common culprit - chemotherapy drugs like Revlimid (lenalidomide) frequently cause diarrhea by affecting how your intestines absorb bile salts.

Revlimid can cause late-onset diarrhea appearing 17-24 months after starting treatment. A MyMyelomaTeam member shared: "I had never-ending diarrhea from Revlimid. So much so, that when it was deemed to be a continued response, my oncologist discontinued it."

Here are strategies that may help:

Dietary changes:
- Well-cooked vegetables
- Peeled canned fruits
- White rice and white bread
- Yogurt
- Lean, skinless meats (baked or broiled)
- Smooth peanut butter
- Cooked eggs with solid whites

Stay hydrated: Drink 8-12 cups of room-temperature water daily. Clear liquids like broth can help replace lost fluids.

Medications: Over-the-counter options like Imodium or prescription bile acid sequestrants may help. One member found success: "My husband takes half an Imodium and one packet of cholestyramine, split into two doses. It does help him."

Always contact your doctor before trying any treatments, as they need to ensure nothing interferes with your myeloma therapy.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Multiple Myeloma and Bowel Problems: Diarrhea, Constipation, and More