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A MyMyelomaTeam Member asked a question 💭
Lee, MA

On February 17, 2026, the FDA reached a major milestone in the fight against multiple myeloma by accepting the New Drug Application (NDA) for iberdomide. This drug is the first of its kind in a brand-new class of oral therapies called CELMoDs (Cereblon E3 Ligase Modulators). If approved, the "IberDd" regimen could transform how the disease is managed, especially for those who have already tried traditional treatments.

The News at a Glance

• The Drug: Iberdomide (an oral, first-in-class… read more

March 3
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Answer Summary

Members expressed excitement about the FDA's acceptance of iberdomide, a promising new oral CELMoD therapy for relapsed multiple myeloma, with... Read more

Members expressed excitement about the FDA's acceptance of iberdomide, a promising new oral CELMoD therapy for relapsed multiple myeloma, with one member actively participating in a clinical trial reporting excellent lab results and minimal side effects after a year of treatment. Several members shared practical concerns about access and affordability, including Medicare Part D coverage timelines (which typically begin within the first year after FDA approval), the high cost of similar drugs like Revlimid, and the requirement that patients must have 1-2 prior treatment lines before qualifying. A recurring theme was cautious optimism, balancing hope for a more effective and tolerable treatment option with real-world worries about whether this breakthrough will be financially accessible to those who need it most.

A MyMyelomaTeam Member

My hematologist spoke about this drug at my last visit. He was extremely positive and excited that the side effects were so few compared to the predecessors in this drug class. Smaller dose -- better impact -- less side effects.

March 3
A MyMyelomaTeam Member

This is fantastic news. I hope it works as well as they say. It gives new hope to so many of us.

March 4
A MyMyelomaTeam Member

JamieW, thank you for this information! I have been in the COMMANDER study at University of Alabama-Birmingham investigating the use of iberdomide since February 2025. I have been doing very well, very good labs, and very few side effects. A BMB is scheduled for this summer to assess MRD. My doctor told me that many of the other study participants who have been involved for going on 3 years continue to show very good responses. I am excited to hear that this treatment is on track to be more widely offered. I am also grateful that there are many new treatments being developed and remain optimistic that there will be a discovery that will prevent these abnormal cells from being produced in the first place!!!

March 3
A MyMyelomaTeam Member

Hey JamieW, the first 6 months my treatment was DarzalexFaspro and dexamethasone weekly, then biweekly while taking iberdomide 21 days on, 7 days off. Beginning in August 2025, my treatment was only iberdomide 21 days on, 7 days off, with labs monthly.

March 3
A MyMyelomaTeam Member

Thanks for the info JamieW, looks like a promising drug with more potency to fight MM and less side effect. Hope it doesn't cost an arm and a leg.

March 4

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A MyMyelomaTeam Member asked a question 💭
Lake Charles, LA