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Remission in multiple myeloma (MM) refers to a state where cancer markers like M-protein and free light chains are significantly reduced or undetectable, leading to symptom relief, though it's not a cure. Chronic kidney disease (CKD) is a common complication in MM, affecting up to 50% of patients due to light chain damage to kidneys.
Remission Definition:
MM remission levels include partial response (≥50% reduction in markers), very good partial response (≥90% reduction), and complete response (no detectable M-protein, <5% myeloma cells in bone marrow). These use International Myeloma Working Group (IMWG) criteria, focusing on blood/urine tests and imaging.
CKD in MM Context:
CKD stages in MM follow standard CKD-EPI eGFR: stage 3 (30-59 mL/min), stage 4 (15-29), stage 5 (<15 or dialysis). MM-related CKD often stems from cast nephropathy, where free light chains clog kidney tubules; rapid reduction via treatment can reverse it in 50-70% of cases.
Remission with CKD:
Achieving MM remission remains possible with CKD using bortezomib-based regimens, which improve kidney function alongside cancer control (e.g., 73% renal reversal rate). IMWG defines separate renal response: partial (≥25% creatinine clearance improvement), complete (to >60 mL/min). Prognosis improves if kidneys recover during remission, though survival lags behind non-CKD patients.
It’s a short period maybe 2 years or less mine was after transplant where you aren’t on toxic chemo drugs.
How can you manage weakness, body pain, and joint pain while in remission with chronic kidney disease?
It's common to experience ongoing symptoms like weakness, body pain, and joint discomfort even when in remission. A MyMyelomaTeam member shared, "My legs and body hurt all the time," while another noted, "I seem to be Show Full Answer
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