Oh... I wish Acyclovir made me tired- take twice daily. Steroids are my biggest side effect- awake overnight and nap during the day.

Yes, it can. They are listed as a potential side effects though not everyone has those symptoms. They are listed in the attached under "What are some mild side effects of acyclovir".

Acyclovir Side Effects: Common, Severe, Long Term https://share.google/2J8BZpJ5y4UTfoyrs

Kathryn I with you. I have no stamina at all. I get breathless just going up and the stairs. Before being diagnosed I was doing 3 miles a day on my bike and walking a mile. Diagnosed in September of 2024. Did 6 cycles of 4 drug regiment and now on maintenance of Darzalex fas pro once a month, acyclovir 2 pills daily and Dexamethasone every other week. The Dexamethasone keeps me up for 24-36 hours. But I think you are right about the acyclovir could be making me drowsy and also causing balance issues.
Take care Kathryn, hope this helps.
Will

It does not appear to make me drowsy; I've been on it for almost a year.

I’ve been talking it for 2-3 years, and it doesn’t make me drowsy