Does having chromosome deletions change the watch-and-wait approach for smoldering multiple myeloma?
Having chromosome deletions, particularly deletion of chromosome 13, can be significant. Certain chromosome changes are considered "high-risk" features in myeloma and may affect treatment decisions.
Deletion of all or part Show Full Answer
Does having chromosome deletions change the watch-and-wait approach for smoldering multiple myeloma?
Having chromosome deletions, particularly deletion of chromosome 13, can be significant. Certain chromosome changes are considered "high-risk" features in myeloma and may affect treatment decisions.
Deletion of all or part of chromosome 13 is one of the chromosome changes that can indicate a worse outlook and more aggressive disease. When someone with smoldering multiple myeloma has high-risk genetic features like this, doctors may recommend early treatment rather than watchful waiting.
In recent years, there's been a shift toward treating "high-risk" smoldering multiple myeloma earlier. High-risk cases are defined by specific criteria, including:
* Certain genetic abnormalities in the cancer cells
* High levels of plasma cells in bone marrow
* High levels of M protein in blood
* Bone lesions visible on imaging
The presence of these chromosome deletions could potentially move you from a standard watch-and-wait approach to consideration of early treatment. However, your doctor will look at all your test results together - including your M protein levels, plasma cell percentage, and other factors - to determine the best approach for your specific situation.
It's important to discuss these genetic findings with your hematologist to understand what they mean for your individual treatment plan.
January 10
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