Are you considering stopping Darzalex and denosumab injections due to lower back pain while on oral chemotherapy?
It's understandable that continuous lower back pain is making you reconsider your treatment plan. However, before making this decision, it's important to understand what might be causing the pain and explore Show Full Answer
Are you considering stopping Darzalex and denosumab injections due to lower back pain while on oral chemotherapy?
It's understandable that continuous lower back pain is making you reconsider your treatment plan. However, before making this decision, it's important to understand what might be causing the pain and explore other options.
Potential causes of your back pain:
- Darzalex (daratumumab) can cause back pain as a side effect
- Denosumab is actually a bone-building medication designed to prevent bone problems and fractures that cause pain
- The oral chemotherapy itself might be contributing
- Myeloma-related bone damage or lesions could be the underlying issue
Important considerations:
Stopping denosumab could actually increase your risk of bone fractures and worsen pain over time, since it's protecting your bones from myeloma damage. Darzalex is a key treatment that helps fight myeloma cells.
What you can do:
Talk with your doctor about the specific source of your pain. They may recommend:
- Pain management strategies (physical therapy, heating pads, pain relievers)
- Adjusting medication timing or dosages
- Treating underlying bone issues with procedures like kyphoplasty if you have fractures
- Complementary therapies like acupuncture or yoga
A MyMyelomaTeam member shared that radiation helped their back pain from lesions pressing on nerves, while another found physical therapy gave them what they needed to walk again.
Don't make changes to your treatment plan without discussing alternatives with your healthcare team first.
December 30, 2025
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