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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
November 20, 2025
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A MyMyelomaTeam Member

I guess that's me. I don't usually have much pain. My labs are good. Still mrd positive. I do have aches and pains from time to time. I'm 66 years old. I've had myeloma for 9 years.

November 21, 2025
A MyMyelomaTeam Member

The m protein measures your monoclonal proteins in your blood. I don't think it has a direct correlation with pain. In some patients it could. It depends on the type of myeloma you have. My m spike was pretty high at diagnosis. I only had some pain in my right rib cage. Some people have a lot of bone involvement. I can imagine their pain can be tremendous. An m spike of 0.0 is our goal🥰

November 21, 2025 (edited)
A MyMyelomaTeam Member

I second what Donna stated. Upon diagnosis , I had an astronomically high m-spike and my pain level was also extreme. Now that I have no mSpike (I feel so thankful ) , my pain level is zero as well. Is there a correlation? I’m not sure - wishing you all the best Holiday season with all mSpikes bottoming to zero 💜

November 21, 2025
MyMyelomaTeam

Does the M spike number indicate how much pain you might experience with myeloma?

The M spike number doesn't directly determine pain levels. While M protein tests help diagnose and monitor myeloma, pain is more closely related to where and how the disease affects your body.

Pain in myeloma typically comes from:

- Bone Show Full Answer

Does the M spike number indicate how much pain you might experience with myeloma?

The M spike number doesn't directly determine pain levels. While M protein tests help diagnose and monitor myeloma, pain is more closely related to where and how the disease affects your body.

Pain in myeloma typically comes from:

- Bone lesions and tumors that weaken bones
- Fractures in the spine, hips, ribs, or skull
- Spinal cord compression from vertebral collapse
- Nerve damage (peripheral neuropathy)
- Treatment side effects from certain medications

The location and severity of bone damage matters more for pain than M protein levels. For example, vertebral fractures can cause significant back pain and nerve compression, while hip lesions may make walking painful.

Other factors affecting pain include:

- How well bones are healing
- Whether tumors are pressing on nerves
- Your specific treatment medications
- Kidney function

Your overall disease burden and bone health are better indicators of potential pain than M spike numbers alone. Working with your medical team on pain management is important regardless of M protein levels.

November 20, 2025
A MyMyelomaTeam Member

My MSpike upon diagnosis was about 4.5 and came with a broken neck and arm. That was 11 months ago —So I was in tremendous pain for about 3 -6 months- Now, and I have ZERO pain and still have Mspike at .81 , It’s slowly continuing to drop- but for me clearly I don’t have to be i a full remission to be pain free. I’m very grateful for that. My bones apparently have lyric lesions but no pain and pretty good labs. I’d be perfectly fine to stay like this for years!!

November 21, 2025

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