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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Is running a low fever under 100 normal during DRVD?

A MyMyelomaTeam Member asked a question 💭
Santa Monica, CA
November 16, 2025
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A MyMyelomaTeam Member

It can be normal. But with cancer it's complicated. When we don't have adequate white cells we don't always run a fever like people who don't have a compromised immune system. I would let your provider know.

November 16, 2025 (edited)
MyMyelomaTeam

Is running a low fever under 100°F normal during DRVD treatment?

Low-grade fevers can occur as a side effect during myeloma treatment. One MyMyelomaTeam member mentioned experiencing "fatigue, fevers, can't sleep, muscle cramps" while staying active during treatment.

However, fevers can also signal infections, which is Show Full Answer

Is running a low fever under 100°F normal during DRVD treatment?

Low-grade fevers can occur as a side effect during myeloma treatment. One MyMyelomaTeam member mentioned experiencing "fatigue, fevers, can't sleep, muscle cramps" while staying active during treatment.

However, fevers can also signal infections, which is particularly important since myeloma treatments can weaken your immune system. It's worth checking with your healthcare team about:

- Whether this is an expected side effect of your specific treatment regimen
- Any precautions you should take to avoid infections
- Signs of more serious complications you should watch for

Even if the fever seems minor, it's always better to report it to your doctor so they can determine if it's a normal treatment response or something that needs attention.

November 16, 2025

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