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What LDH levels define stage 2 and stage 3 multiple myeloma?

For stage 2 multiple myeloma, the Revised International Staging System doesn't specify exact LDH levels. Stage 2 is diagnosed when someone has features that fall between stage 1 and stage 3 - meaning they don't meet all the criteria for stage 1 but don't meet the Show Full Answer

What LDH levels define stage 2 and stage 3 multiple myeloma?

For stage 2 multiple myeloma, the Revised International Staging System doesn't specify exact LDH levels. Stage 2 is diagnosed when someone has features that fall between stage 1 and stage 3 - meaning they don't meet all the criteria for stage 1 but don't meet the criteria for stage 3 either.

Stage 1 requires normal LDH levels, while stage 3 requires elevated LDH levels (along with other factors). Stage 2 can include people with various LDH levels that don't fit neatly into either category.

For stage 3 multiple myeloma, high LDH levels are one of the defining characteristics. To be diagnosed with stage 3, you need a beta-2 microglobulin level of 5.5 milligrams per liter or higher, plus either high-risk genetic abnormalities OR elevated LDH levels.

The staging system focuses more on whether LDH is normal versus elevated rather than providing specific numerical cutoffs for each stage.

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