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November 20, 2025
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A MyMyelomaTeam Member

Paula - Thanks for your info. It appears, with my limited knowledge, that my husband may have the same type MM as you. His IgA is extremely high (IgG & IgM extremely low), Kappa Light Chain is high & Lambda low. I am going to review his lab results & look at his creatinine levels. As far as we know, he does not have bone lesions that so many MM patients have. He had a PET scan but we won't know the results of it until his appointment Monday with the doctor. You have been extremely helpful and I thank you again! By the way, I have ordered the book.

November 22, 2025 (edited)
A MyMyelomaTeam Member

It is complicated! I watch my creatinine, because I have IgA Kappa, which can affect the kidneys. A high creatinine is bad. Of course, M-Spike is a big one too. I highly recommend Dr Brandy’s book “Beat Back Cancer Naturally.”
Paula 🌹

November 21, 2025
A MyMyelomaTeam Member

Debbie,
First your husband needs to see a Hematologist/ Oncologist who specializes in MM. If your’s does not, ask for a referral for a second opinion. Your doctor will be happy to work with the MM Specialist. Many people do not live near a MM Specialist, but that’s no problem now with the Internet. You can conference with them on-line. Even if your doctor is a MM Specialist, it’s important to get a second opinion. Second after all the blood tests mentioned above, he needs a bone marrow biopsy. I like MyChart because I can see all my medical records on-line and keep track of my test results. There are certain test results we watch to see how we are doing, like the ones mentioned in the AI response. The Multiple Myeloma Research Foundation is a great place to start for information and the name of a MM Specialist. They also have Counselors you can talk to, to help you in your journey, some who also have Multiple Myeloma. HTTPS://themmrf.org/ This site will help you understand the difference between low risk and high risk and what markers to look for. Once you know what type of MM he has, share it on your story. It will help you connect with others like yourself. This site also has lots of information.
Paula🌹

November 20, 2025 (edited)
MyMyelomaTeam

How is the type and stage of multiple myeloma determined?

Understanding your husband's specific type and stage requires certain blood tests and genetic testing. It's completely reasonable to ask his doctor for more details about his diagnosis.

To determine the type of myeloma, doctors typically test for:

- Which antibody Show Full Answer

How is the type and stage of multiple myeloma determined?

Understanding your husband's specific type and stage requires certain blood tests and genetic testing. It's completely reasonable to ask his doctor for more details about his diagnosis.

To determine the type of myeloma, doctors typically test for:

- Which antibody proteins the myeloma cells are producing (like IgG, IgA, or light chains only)
- Whether it's producing kappa or lambda light chain proteins
- In about 15% of cases, only light chain proteins are made (called light chain myeloma)

To determine the stage, doctors use the Revised International Staging System (R-ISS), which measures:

- Beta-2 microglobulin levels in blood
- Albumin levels in blood
- Lactate dehydrogenase (LDH) levels
- Genetic abnormalities through FISH testing (fluorescence in situ hybridization)

The R-ISS classifies myeloma into three stages based on these test results. When the doctor mentions "aggressive," this could refer to high-risk genetic changes found in the FISH test or elevated LDH levels, both of which suggest faster-progressing disease.

It would be helpful to ask the doctor specifically:
- What are his beta-2 microglobulin and albumin levels?
- What stage is it (1, 2, or 3)?
- Were high-risk genetic abnormalities found?
- What type of myeloma protein is present?

This information will help you both understand his diagnosis better and what treatment approach might be recommended.

November 20, 2025
A MyMyelomaTeam Member

My PET scan lit up on my arms and legs, but I had no lytic lesions. It may have just picked up inflammation . I thought a test like that would be more definitive.
Paula🌹

November 22, 2025

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