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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMyelomaTeam Member asked a question đź’­
Santa Ana, CA

Mine lit up bright yellow on my shoulders, lower arms, back of knees and outer lower legs. Is this just inflammation?

November 5, 2025
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A MyMyelomaTeam Member

Good morning! PET scans are "fun." Sorry you had to have one. I've had 3 this year after a relapse. Areas of activity have shown up on bones and lymph nodes. (My swollen clavicular lymph nodes were the big indicator of the relapse.)
The day before the PET scan, I eat only meat, vegetables and cheese - no caffeine and no carbs. (Yes, I am a terror the day before a PET Scan!) 🤣. I was also told to sit around and watch television and absolutely no exercise, as that might cause muscles to "light up" on the scan. (Not saying that is what happened in your case, just sharing what I know, which probably isn't much.).
Hope you are doing ok. I know you have several health issues you are managing. Take care, and God bless! 🙏🏻♥️

November 6, 2025
A MyMyelomaTeam Member

I only paid attention to the bones, mostly ribs and definitly my hips. Large lesions there. I think i am due for another one soon.

November 5, 2025
A MyMyelomaTeam Member

My last PET lit up on my right side glute after a fall. It was the inflammation of the muscles.

November 5, 2025
A MyMyelomaTeam Member

One of my PET scans showed activity in my left femur, so far, never in any muscles.

November 5, 2025
MyMyelomaTeam

Did your PET scan show uptake in muscles rather than bones?

PET scans use a radioactive sugar solution that cells absorb for energy. Cancer cells typically use more energy than healthy cells, which is why they light up brightly on PET scans.

However, muscles can also show uptake on PET scans, especially if they've been Show Full Answer

Did your PET scan show uptake in muscles rather than bones?

PET scans use a radioactive sugar solution that cells absorb for energy. Cancer cells typically use more energy than healthy cells, which is why they light up brightly on PET scans.

However, muscles can also show uptake on PET scans, especially if they've been active or stressed before the scan. This can happen from:

* Recent exercise or physical activity
* Muscle tension or strain
* Inflammation in the muscles

The areas you mentioned—shoulders, lower arms, back of knees, and outer lower legs—are common sites for muscle uptake, particularly if you used these muscles before your scan.

While inflammation could be a factor, it's important to discuss these specific findings with your healthcare team. They can review your complete scan results along with your other tests and symptoms to determine whether this uptake is related to myeloma, inflammation, or simply muscle activity.

Your doctor may recommend additional imaging or tests if there's any concern about what's causing the uptake in these areas.

November 5, 2025

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A MyMyelomaTeam Member asked a question đź’­
Santa Ana, CA

A MyMyelomaTeam Member asked a question đź’­