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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMyelomaTeam Member asked a question 💭
September 8, 2025
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Historically, the main approach for treating smoldering multiple myeloma (SMM) has been "watchful waiting" or "watch and wait." This involves regular follow-up visits and testing to monitor the condition's progression. The benefit of this approach is that patients can avoid treatment side effects while still catching any Show Full Answer

Historically, the main approach for treating smoldering multiple myeloma (SMM) has been "watchful waiting" or "watch and wait." This involves regular follow-up visits and testing to monitor the condition's progression. The benefit of this approach is that patients can avoid treatment side effects while still catching any progression to active myeloma early. However, recent evidence suggests that earlier treatment may improve outcomes, particularly for those with high-risk SMM. Current treatment options include:

• Bisphosphonates to strengthen bones and prevent bone damage
Revlimid (lenalidomide) combined with low-dose Decadron (dexamethasone) may help reduce the chances of developing active myeloma in high-risk cases
• Clinical trials exploring new treatment approaches

Your healthcare team will determine the best treatment approach based on your risk level and specific circumstances.

September 8, 2025

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A MyMyelomaTeam Member asked a question 💭
Rhinelander, WI