Historically, the main approach for treating smoldering multiple myeloma (SMM) has been "watchful waiting" or "watch and wait." This involves regular follow-up visits and testing to monitor the condition's progression. The benefit of this approach is that patients can avoid treatment side effects while still catching any Show Full Answer
Historically, the main approach for treating smoldering multiple myeloma (SMM) has been "watchful waiting" or "watch and wait." This involves regular follow-up visits and testing to monitor the condition's progression. The benefit of this approach is that patients can avoid treatment side effects while still catching any progression to active myeloma early. However, recent evidence suggests that earlier treatment may improve outcomes, particularly for those with high-risk SMM. Current treatment options include:
• Bisphosphonates to strengthen bones and prevent bone damage
• Revlimid (lenalidomide) combined with low-dose Decadron (dexamethasone) may help reduce the chances of developing active myeloma in high-risk cases
• Clinical trials exploring new treatment approaches
Your healthcare team will determine the best treatment approach based on your risk level and specific circumstances.
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Smoldering Multiple Myeloma: Your Guide
September 8, 2025