In multiple myeloma, plasma cells produce abnormally high amounts of specific antibodies. Here's what's typically seen:
• About 50% of myeloma patients have abnormally high IgG levels
• Approximately 20% have abnormally high IgA levels
• IgM myeloma is very rare Doctors use several tests to measure these levels:
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In multiple myeloma, plasma cells produce abnormally high amounts of specific antibodies. Here's what's typically seen:
• About 50% of myeloma patients have abnormally high IgG levels
• Approximately 20% have abnormally high IgA levels
• IgM myeloma is very rare Doctors use several tests to measure these levels:
• Immunofixation electrophoresis (IFE) - Shows which specific type of abnormal antibody is present
• Quantitative immunoglobulins test - Measures overall antibody levels in blood
• 24-hour urine tests - Can detect abnormal proteins that may not show up in blood tests
These measurements help doctors diagnose myeloma, plan treatments, and monitor disease progression. IgA myeloma typically has a worse prognosis than IgG myeloma, which may influence treatment decisions.
September 6, 2025