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How to manage rashes and itchy skin as a side effect of Lenalidomide?

A MyMyelomaTeam Member asked a question 💭
Bhavnagar, Gujarat, India

I am currently in remission and taking 25mg Lenalidomide as maintenence drug. But as a potential side effect of Lenalidomide, I am suffering from little rashes and itchy skin. Can anyone suggest the drug to get rid of rashes and itchy skin? Please suggest how to manage rashes and itchy skin because of Lenalidomide.

August 14, 2025
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A MyMyelomaTeam Member

Vikram
I started chemo with 25mg Linalidomide and at one time it caused me all body itchy and having red spots on the hand and neck. The doctor put me in the ward for observation, and changed my dosage to 10mg twice a day and acyclovir 400 mg morning and night every day.
Now I have no issues, the itchy are gone.
Thank to God for helping me because when I having the itchy side effects, l like a mad person can’t stay still and shouting loud because of the itchiness my hand never stops from rubbing my hole body and I immediately went to the A&E
Hope your itchy is a normal type if it getting worse,go to see your doctor 🙏🤨

August 14, 2025
A MyMyelomaTeam Member

I just started on 5 mg of Lenalidomide 5 days ago and I was really itching on My head and also my ears were getting hives anyway I tried Benadryl and it didn't work but Claritin worked perfect. Just plain Claritin not with a D.

August 17, 2025 (edited)
A MyMyelomaTeam Member

Get your lungs checked regularly as lenilomide can cause pneumosis which is often mistaken for pneumonia

August 17, 2025
A MyMyelomaTeam Member

Thanks Mad for your useful reply.

August 14, 2025
MyMyelomaTeam

Rashes and itchy skin are common side effects of lenalidomide (Revlimid). In fact, studies show that about 19% of patients develop itchy rashes while on this medication. While this can be uncomfortable, it's important to note that some research suggests that rashes caused by lenalidomide may actually be linked to higher Show Full Answer

Rashes and itchy skin are common side effects of lenalidomide (Revlimid). In fact, studies show that about 19% of patients develop itchy rashes while on this medication. While this can be uncomfortable, it's important to note that some research suggests that rashes caused by lenalidomide may actually be linked to higher survival rates. If you're experiencing rashes and itching, it's essential to:

• Tell your healthcare team about any skin changes during follow-up visits
• Monitor and document when the rashes appear
• Note if they come and go with treatments
• Discuss with your doctor about possible adjustments to your maintenance therapy if symptoms are severe

Remember that lenalidomide is generally well-tolerated and is a standard maintenance therapy option, but your comfort matters. Your doctor may be able to prescribe appropriate medications to help manage the skin reactions while maintaining your treatment schedule.

August 14, 2025

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