MGUS (Monoclonal Gammopathy of Undetermined Significance) is a blood disorder where abnormal proteins called M proteins are found in the blood. Research has shown interesting connections between autoimmune conditions and MGUS, with studies indicating that people with certain autoimmune conditions may have a higher Show Full Answer
MGUS (Monoclonal Gammopathy of Undetermined Significance) is a blood disorder where abnormal proteins called M proteins are found in the blood. Research has shown interesting connections between autoimmune conditions and MGUS, with studies indicating that people with certain autoimmune conditions may have a higher likelihood of developing MGUS.
The relationship appears to be complex, and researchers are still working to fully understand these connections. What is known is that MGUS affects about 2-3% of people over age 50, increasing to about 5% in those over 70. Risk factors for developing MGUS include:
• Being older
• Being male
• Being Black
• Having a family history of MGUS or multiple myeloma
It's important to note that MGUS itself usually doesn't cause symptoms, but regular monitoring through blood and urine tests every 6-12 months is recommended to check for any changes.
August 7, 2025