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A MyMyelomaTeam Member asked a question 💭
Portsmouth, NH

My immunoglobulin G is 888 and immunoglobulin A is 113 and immunoglobulin M is 125 all normal range, but all trending lower what does that mean in relation to smoldering myeloma. I do have more pain in my back lower hip wrapping around into my pelvis. What are your thoughts?

July 17, 2025
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A MyMyelomaTeam Member

I have had severe back pain. It is arthritis and I also have stenosis. I had surgery in December but I am still experiencing severe back pain. I have tried injections, a back brace and next is diagnostic injections. Supposedly has nothing to do with MM.

July 18, 2025
A MyMyelomaTeam Member

@A MyMyelomaTeam Member that’s good that your numbers are within normal range! The hip pain maybe arthritis. I have similar pain and it concerned me too, they ordered x-rays and said it was bilateral hip osteoarthritis, so yours may be the same thing. I hope you find some relief and keep us posted on the rest of your results.

July 17, 2025
A MyMyelomaTeam Member

Hi John- these are good numbers and good news. I’ve suffered some pretty horrible lower back pain myself, always from herniated or bulging discs. The nerves in this area are numerous and branch out in different directions. We always talk about the obvious sciatic nerve running down the leg but there are a number of nerves from the lumbar plexus (L1-L4) region that radiates to the front of the abdomen. Maybe an MRI is needed to see what’s going on in your lower back? Best case, if this is the problem, a steroid injection can calm the nerves down for you. Of course if the problem is more serious, like a major bulge against the disc it could require shaving the disc back. I’ve had to do that in the past. It doesn’t sound like you ruptured a disc or cracked it.

September 27, 2025
MyMyelomaTeam

While your immunoglobulin levels are in normal range, it's important to note that smoldering multiple myeloma (SMM) is typically diagnosed when tests show elevated protein levels. However, doctors use multiple tests beyond just immunoglobulin levels to monitor SMM, including:

• Serum protein electrophoresis
• Urine protein Show Full Answer

While your immunoglobulin levels are in normal range, it's important to note that smoldering multiple myeloma (SMM) is typically diagnosed when tests show elevated protein levels. However, doctors use multiple tests beyond just immunoglobulin levels to monitor SMM, including:

• Serum protein electrophoresis
• Urine protein electrophoresis
• Immunofixation electrophoresis
• Serum-free light-chain assay Regarding your pain symptoms - this is important to discuss with your healthcare provider. While SMM typically doesn't cause symptoms, the development of symptoms like bone pain could be significant. Your doctor may want to perform additional tests, including bone marrow tests, to properly evaluate your condition and determine if there have been any changes in your status.

July 17, 2025

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