Yes and yes. Standard risk often does mutate and get high risk markers at relapse. Myeloma is a blood cancer, so unlike solid tumors if can be restaged at relapse
May 11, 2025
That being said, could stage also change at relapse?
May 11, 2025
Yes, a multiple myeloma patient's risk status can change over time, particularly after relapse. Most people respond well to their first-line therapy for about 2-3 years before experiencing a relapse. When relapse occurs, doctors need to completely reevaluate the treatment plan since the disease characteristics may have Show Full Answer
Yes, a multiple myeloma patient's risk status can change over time, particularly after relapse. Most people respond well to their first-line therapy for about 2-3 years before experiencing a relapse. When relapse occurs, doctors need to completely reevaluate the treatment plan since the disease characteristics may have changed. The timing of relapse can indicate risk level - very early relapses, especially within the first year after treatment, may suggest high-risk disease. If minimal residual disease (MRD) is detected after treatment is complete, it often indicates a higher likelihood of earlier relapse. Your hematologist-oncologist will use various testing methods including blood work, imaging, and bone marrow analysis to assess disease status and risk level after relapse.
May 11, 2025