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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
May 11, 2025
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A MyMyelomaTeam Member

Yes and yes. Standard risk often does mutate and get high risk markers at relapse. Myeloma is a blood cancer, so unlike solid tumors if can be restaged at relapse

May 11, 2025
A MyMyelomaTeam Member

That being said, could stage also change at relapse?

May 11, 2025
MyMyelomaTeam

Yes, a multiple myeloma patient's risk status can change over time, particularly after relapse. Most people respond well to their first-line therapy for about 2-3 years before experiencing a relapse. When relapse occurs, doctors need to completely reevaluate the treatment plan since the disease characteristics may have Show Full Answer

Yes, a multiple myeloma patient's risk status can change over time, particularly after relapse. Most people respond well to their first-line therapy for about 2-3 years before experiencing a relapse. When relapse occurs, doctors need to completely reevaluate the treatment plan since the disease characteristics may have changed. The timing of relapse can indicate risk level - very early relapses, especially within the first year after treatment, may suggest high-risk disease. If minimal residual disease (MRD) is detected after treatment is complete, it often indicates a higher likelihood of earlier relapse. Your hematologist-oncologist will use various testing methods including blood work, imaging, and bone marrow analysis to assess disease status and risk level after relapse.

May 11, 2025

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Nashua, NH