In multiple myeloma, plasma cells (a type of white blood cell) become cancerous and produce abnormal antibody proteins called immunoglobulins. Healthy plasma cells normally make different types of antibodies that help fight infections. However, when myeloma develops, these cells don't function correctly.
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In multiple myeloma, plasma cells (a type of white blood cell) become cancerous and produce abnormal antibody proteins called immunoglobulins. Healthy plasma cells normally make different types of antibodies that help fight infections. However, when myeloma develops, these cells don't function correctly.
The most common types of abnormal immunoglobulins in myeloma are IgG (found in about half of cases) and IgA (found in about 20% of cases). When these levels are low, it can indicate that the cancerous plasma cells are crowding out the healthy ones that would normally produce functional antibodies. Low immunoglobulin levels can make you more susceptible to infections since your body has fewer functioning antibodies to fight off bacteria and viruses. If you're experiencing frequent or long-lasting infections, your doctor may order blood tests to check your white blood cell count and immunoglobulin levels to monitor your myeloma status.
April 22, 2025