In multiple myeloma, abnormal plasma cells (a type of white blood cell) produce excessive amounts of abnormal proteins called immunoglobulins. These immunoglobulins are made up of heavy and light chain proteins. When myeloma cells multiply, they often produce more light chains than needed for making antibodies.
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In multiple myeloma, abnormal plasma cells (a type of white blood cell) produce excessive amounts of abnormal proteins called immunoglobulins. These immunoglobulins are made up of heavy and light chain proteins. When myeloma cells multiply, they often produce more light chains than needed for making antibodies.
The higher the percentage of abnormal plasma cells, the more abnormal proteins are typically produced. This can be measured through blood tests that look at serum free light chains (SFLC). Doctors can track disease progression by measuring specific proteins in the blood, including beta-2 microglobulin and M protein levels. Higher levels of these proteins often indicate more advanced disease and a greater presence of myeloma cells. Regular monitoring of these protein levels helps doctors assess how the disease is progressing and determine the effectiveness of treatment.
April 22, 2025