Connect with others who understand.

  • Learn from expert-reviewed resources
  • Real advice from people who’ve been there
  • People who understand what you’re going through
Sign Up Log In
Powered By
Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
March 31, 2025
 · 
Reactions
MyMyelomaTeam

Recent studies show encouraging results for stem cell transplants (SCT) in myeloma treatment. The five-year survival rate for people who undergo bone marrow transplants has significantly improved from 35% to 63%, thanks to better drug combinations used alongside the transplant. Regarding relapse, it's important to Show Full Answer

Recent studies show encouraging results for stem cell transplants (SCT) in myeloma treatment. The five-year survival rate for people who undergo bone marrow transplants has significantly improved from 35% to 63%, thanks to better drug combinations used alongside the transplant. Regarding relapse, it's important to understand that while SCT can provide extended remission periods, relapses are common in myeloma. Studies show that about 16% of people relapse within one year after treatment, and approximately 50% experience a relapse within 27 months of completing their first-line therapy.

The timing of relapse can significantly impact prognosis - those who maintain remission longer typically have better outcomes. Your healthcare team will monitor you closely after SCT using blood work, imaging tests, and specialized testing like MRD (minimal residual disease) to detect any early signs of relapse.

March 31, 2025
A MyMyelomaTeam Member

Part 2:

1)"Conclusions
Among adults with multiple myeloma, RVD plus ASCT was associated with longer progression-free survival than RVD alone. No overall survival benefit was observed. (Funded by the National Heart, Lung, and Blood Institute and others; DETERMINATION ClinicalTrials.gov number, NCT01208662.)"

2)"In that trial, in which patients had multiple effective treatment options at relapse and in which many received ASCT after RVD alone, no overall survival benefit of RVD plus ASCT was evident after a median follow-up of more than 7 years."

3)"Safety
The most common treatment-related adverse events that occurred during the entire trial treatment period are summarized in Table S2. Treatment-related events of grade 3 or higher occurred in 279 patients (78.2%) in the RVD-alone group and 344 patients (94.2%) in the transplantation group; 60.5% and 89.9%, respectively, reported treatment-related hematologic adverse events of grade 3 or higher"

4)"However, despite a median follow-up of more than 6 years in our trial, approximately one quarter of the patients had died, and given the lengthy median overall survival among patients in this population in general, we did not observe an overall survival advantage of RVD plus ASCT over RVD alone."

5) "With longer-term use of lenalidomide in the DETERMINATION trial, the 5-year cumulative incidence of second primary hematologic cancers was 1.6% with RVD alone, as compared with 3.5% with RVD plus ASCT"

6) "In the absence of a demonstrated overall survival benefit, however, and in the context of considerations regarding real-world factors such as treatment burden, acute and long-term toxic effects, patient preference, and quality of life, these findings may be taken into account when making treatment decisions."

March 31, 2025
A MyMyelomaTeam Member

That is the question and we don't know everyone is different
I h a d mine in 2018 just one small relapse. Went from 10 MG revlimid to 10 then after a bit went back to 5

March 31, 2025
A MyMyelomaTeam Member

Sorry Vince, but I haven't had to undergo a SCT. I am in remission for over 15 years now. I was on oral chemo for most of than time with the drug Revlamid. I wish you well with your Stem Cell Transplant. Pedro

March 31, 2025
A MyMyelomaTeam Member

So, I've passed the 27month criteria and encouraged to know my chances are not bad.

March 31, 2025

Related Questions

View All