I was told by my doctor, without reference to chromosome 13, that mine is a high-risk form of MM. That meant, in practical terms, that I would be on maintenance chemo from now on.
In the LLS publication, Myeloma, 2023 Edition,
on p13, Table 2 lists the 13q del as a high prognostic risk: "High, might be involved in bortezomib resistance"
The same table says that it accounts for 45-50% of cytogenetic abnormalities in myeloma.
This publication is free from the Leukemia & Lymphoma Society. Just go online to their website to ask for a copy. They have other myeloma booklets, as well.
By the way, my condition has responded well to treatment. I'm going eight years since my diagnosis in October 2015.
Best wishes.
DGBurk

Who knows what a new biopsy would show?
BTW, thanks for the hugs.

I didn’t have Monosomy 13 when I was first diagnosed with MGUS. As I progressed I added more high risk markers, like monosomy 13.
Paula

I looked closely at my report from 2015. I did not see any positive result showing any chromosome 13 damage. I may be misreading it, but I don't think so.

I read somewhere that it was a high risk factor in the past, but now they have drugs to combat it, when before they didn't.
Paula