My Consulting Doc from Johns Hopkins said to me that once I got to Complete Remission (CR) (clonoSEQ - 10 -6, no cancer per million cells), then my original t(4,14) is not likely be to found with a new BMB, but if I were to have MM return, it would probably have the t(4,14) again.

At the 10 -6 CR level, 0 and 1 high risk are basically, the same risk at that point (as per the clonoSEQ longevity charts from their Case Studies).

Jeannette, click on this article of Dr. Lonial from Emory. They use KRD plus transplant for high risk patients. Then KRD for maintenance. Kyprolis did not work for me. Even though it's supposed to work for high risk patients. I was given Darzalex and Pomalyst instead. Which I am still on. Hope this helps💕

I was told once high risk, always high risk. 💗

Sorry I have no answer to your question.

I am also in search of answer for this question. Iwas diagnosed high risk myeloma tripple hit in oct 2021at the age of 72 years & for fifteen days I was on bed may be due to shock of cancer & side effects of vrg regimen medicines or reason not known to me,
But after that 15 days no problem occured up to now ,I am living a normal life, go every where at my own drive car & two wheeler, no physical problem, never had a fever or any illness
Hb 10
Rbc 3.60
Platelet 159
Wbc 5.70
KFT normal parameters
IFE Normal pattern
SPEP NORMAL PATTERN, no m spike
Kappa lamda ratio 1.63
Ldh 249
At present I am in remission for last six months, now I will go for PET-CT & if it is ok then mrd test will be conducted, if you find the answer pl.let me know