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Wyost (denosumab-bbdz) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to help prevent skeletal-related events in adults with multiple myeloma.
Wyost is a type of medication called a RANK ligand (RANKL) inhibitor. It works by blocking RANKL, a protein that helps break down bone. In multiple myeloma, this may help reduce bone damage and lower the risk of serious bone problems.
Doctors prescribe Wyost to help prevent skeletal-related events in adults with multiple myeloma. These problems can include broken bones, pressure on the spinal cord, or the need for radiation or surgery to the bone.
Wyost is given as an injection under the skin by a healthcare provider.
The recommended dose of Wyost for multiple myeloma is 120 milligrams given as an injection under the skin in the upper arm, upper thigh, or abdomen every four weeks.
This information is based on the prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
In clinical studies of Wyost for preventing skeletal-related events in people with multiple myeloma, the most common side effects occurred in about 11 percent to 34 percent of people. These include:
Wyost can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Sandoz, the manufacturer of Wyost, offers the WYOST Co-Pay Program. Eligible people with commercial insurance may pay as little as $0.
The Sandoz One Source program also offers support services such as benefits investigation, prior authorization support, and reimbursement navigation. Sandoz One Source health experts work with your doctor and their office to help navigate the insurance process. To learn more, visit the Sandoz One Source support page or call 800-954-9128.
Before starting Wyost, your doctor will check your calcium level and treat low calcium before you begin treatment. Your doctor should also check if you are pregnant before treatment starts.
Tell your doctor if you have any allergies to denosumab-bbdz or any ingredients in Wyost.
Tell your doctor about all medicines you take, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Some medicines can lower calcium levels and may increase the risk of hypocalcemia.
Do not take Wyost if you have hypocalcemia or if you have had a serious allergic reaction to denosumab products.
Before starting Wyost, tell your doctor if you have:
Wyost is also FDA-approved to:
If you are pregnant, planning to become pregnant, or breastfeeding while taking Wyost, talk with your doctor about the risks and benefits.
Wyost can harm your baby if used during pregnancy. If you can become pregnant, your doctor should check if you are pregnant before you start treatment. Use effective birth control during treatment and for at least five months after your last dose of Wyost.
These answers are fact-checked by our editorial staff.
How effective is Wyost?
In a study of 1,718 people with newly diagnosed multiple myeloma and bone lesions, Wyost worked as well as zoledronic acid at delaying serious bone problems. These problems included fractures, pressure on the spinal cord, or the need for radiation or surgery to the bone.
People who took Wyost and people who took zoledronic acid lived about the same length of time during the study (hazard ratio of 0.90, 95 percent CI, 0.70 to 1.16).
How long does Wyost take to work for multiple myeloma?
In studies of people with newly diagnosed multiple myeloma, Wyost lowered levels of a bone turnover marker called uNTx/Cr by about 75 percent by week 5. These reductions were maintained from weeks 9 to 49 with 120 milligrams given every four weeks.
The study data does not say exactly when a person may notice symptom improvement.
What tests or monitoring are needed with Wyost for multiple myeloma?
Your doctor should check your calcium levels during treatment, especially during the first weeks after starting Wyost. Low calcium levels must be treated before you begin therapy. Calcium, magnesium, and vitamin D may also be given as needed.
Before starting Wyost, your doctor should perform an oral exam and may recommend preventive dental care. Dental checkups may also be recommended during treatment because serious jawbone problems, called osteonecrosis of the jaw, have been reported.
If you can become pregnant, your doctor should check your pregnancy status before starting treatment.
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