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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Talvey

A MyMyelomaTeam Member asked a question 💭
La Puente, CA
October 1
 · 
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A MyMyelomaTeam Member

Do the side effects stay with you

October 1
MyMyelomaTeam

Talvey (talquetamab-tgvs) is an FDA-approved treatment for relapsed or refractory multiple myeloma in adults who have already tried at least four prior lines of therapy.

It works by connecting myeloma cells and T cells (immune cells) together, activating the T cells to destroy the myeloma. It's given as an injection under Show Full Answer

Talvey (talquetamab-tgvs) is an FDA-approved treatment for relapsed or refractory multiple myeloma in adults who have already tried at least four prior lines of therapy.

It works by connecting myeloma cells and T cells (immune cells) together, activating the T cells to destroy the myeloma. It's given as an injection under the skin by a healthcare professional — not at home.

How it's given:
- Treatment starts with smaller "step-up" doses over the first few days
- After that, it's given either once a week or once every two weeks
- Hospital monitoring for 48 hours is required after each step-up dose

How well does it work?
- About 73% of people responded to Talvey
- Around 33–35% had a complete response
- It typically started working within about 1.2–1.3 months Common side effects include:
- Taste changes and dry mouth
- Skin problems, rash, and very dry skin
- Nail problems
- Fatigue and weight loss
- Fever
- Trouble swallowing

Serious side effects to watch for:
- Cytokine release syndrome (CRS) — fever, chills, low blood pressure, trouble breathing
- Neurologic problems — confusion, trouble speaking, seizures
- Serious infections
- Low blood cell counts
- Liver problems

MyMyelomaTeam members who've used Talvey suggest preparing for taste changes early, using products like Biotene for dry mouth and CeraVe for dry skin, and staying in close contact with your care team throughout treatment.

Always talk with your doctor about whether Talvey is right for your situation, and report any side effects promptly.

October 1