My Multiple Myeloma Specialist prescribed Colestipol so you can discuss this with your healthcare team.
3 days ago
Dealing with frequent diarrhea while on Revlimid (lenalidomide) is unfortunately very common — you're definitely not alone in this. Revlimid can cause something called bile acid malabsorption, where the small intestine struggles to absorb bile salts properly, leading to watery stools. It can even show up 17–24 months after Show Full Answer
Dealing with frequent diarrhea while on Revlimid (lenalidomide) is unfortunately very common — you're definitely not alone in this. Revlimid can cause something called bile acid malabsorption, where the small intestine struggles to absorb bile salts properly, leading to watery stools. It can even show up 17–24 months after starting treatment.
Always check with your oncologist before trying any of the options below, including over-the-counter medications. Here are some treatments that may be considered:
- Loperamide (Imodium) — an over-the-counter option that some MyMyelomaTeam members have found helpful
- Cholestyramine — a prescription medication that helps manage bile acid issues; one MyMyelomaTeam member shared their husband takes half an Imodium alongside cholestyramine with good results
- Pepto-Bismol — one MyMyelomaTeam member found this unexpectedly stopped their diarrhea entirely
- Dose adjustment — if diarrhea is severe, your doctor may lower your Revlimid dose or temporarily stop it Dietary changes can also help alongside any medication:
- Eat well-cooked vegetables and white rice
- Choose lean, baked or broiled meats
- Try yogurt and smooth peanut butter
- Stay well hydrated — aim for 8–12 cups of fluid daily
- Eat smaller, more frequent meals
- Keep a food diary to spot any triggers
If diarrhea is severe or causing dehydration, contact your oncologist promptly — it's important not to wait.
3 days ago
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